Fgf21 Impairs Adipocyte Insulin Sensitivity in Mice Fed a Low-Carbohydrate, High-Fat Ketogenic Diet
Figure 6
Glucose tolerance and insulin tolerance tests of wild-type and Fgf21 knockout mice.
(A–C) Blood glucose, insulin, and glucagon levels of 3-month-old wild-type (WT) and Fgf21 knockout (KO) mice fed NC or KD for 6 days (n = 8–12 mice per group; *, P<0.05). (D) A glucose tolerance test (GTT) of 3-month-old wild-type (WT) and Fgf21 knockout (KO) mice fed KD for 6 days (n = 6–10 per group; *, P<0.05; **, P<0.01 vs. wild-type mice fed KD at the same timepoint, #, P<0.05; P<0.01 vs. wild-type mice fed NC at the same timepoint). (E) An insulin tolerance test of wild-type (WT) mice fed NC or KD and Fgf21 knockout (KO) mice fed KD for 6 days (n = 4–7 per group; *, P<0.05 vs. wild-type mice fed KD at the same timepoint).