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Critical Reviews™ in Immunology

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Lipocalin-2 in the Inflammatory Activation of Brain Astrocytes

Volume 35, Issue 1, 2015, pp. 77-84
DOI: 10.1615/CritRevImmunol.2015012127
Submitted: Sep 23 2014 Accepted: Mar 23 2015 Published online: Feb 20 2015
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Shinrye Lee
Korea Brain Research Institute (KBRI), Daegu, Republic of Korea
Mithilesh Kumar Jha
Department of Pharmacology, Brain Science & Engineering Institute, Department of Biomedical Science, BK21 PLUS KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea
Kyoungho Suk (Corresponding author ksuk@knu.ac.kr)
Department of Pharmacology, Brain Science & Engineering Institute, Department of Biomedical Science, BK21 PLUS KNU Biomedical Convergence Program, Kyungpook National University School of Medicine, Daegu, Republic of Korea

ABSTRACT

Lipocalin-2 (LCN2), a secretory protein, regulates diverse cellular processes such as cell death/survival, cell migration/invasion, cell differentiation, iron delivery, inflammation, insulin resistance, and tissue regeneration. Recently, we reported that LCN2 is secreted by brain astrocytes under inflammatory conditions and that it promotes apoptosis, morphological changes, and migration in astrocytes both in vitro and in vivo. Activated astrocytes release LCN2 not only to induce the morphological transformation associated with reactive astrocytosis, but also to promote their own death. Under inflammatory conditions, activated astrocytes also show functional dichotomy similar to the M1/M2 phenotypes of microglia and macrophages. LCN2 is thought to be a chemokine inducer and an autocrine promoter of the classical proinflammatory activation of astrocytes. This article summarizes the current knowledge regarding the role of astrocyte-derived LCN2 as a proinflammatory mediator in the central nervous system and discusses LCN2's role in neuroinflammatory disorders.

KEY WORDS: lipocalin-2, astrocytes, neuroinflammation, central nervous system, chemokine, polarization
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  1. Eilenberg W., Stojkovic S., Piechota-Polanczyk A., Kaun C., Rauscher S., Gröger M., Klinger M., Wojta J., Neumayer C., Huk I., Demyanets S., Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Symptomatic Carotid Atherosclerosis and Drives Pro-inflammatory State In Vitro, European Journal of Vascular and Endovascular Surgery, 51, 5, 2016. Crossref

  2. Suk Kyoungho, Lipocalin-2 as a therapeutic target for brain injury: An astrocentric perspective, Progress in Neurobiology, 144, 2016. Crossref

  3. Dong Yin-Feng, Chen Zheng-Zhen, Zhao Zhan, Yang Dan-Dan, Yan Hui, Ji Juan, Sun Xiu-Lan, Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation, Journal of Neuroinflammation, 13, 1, 2016. Crossref

  4. Mazzio Elizabeth A, Bauer David, Mendonca Patricia, Taka Equar, Soliman Karam F.A., Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2− in LPS/IFNγ activated glioma cells, Journal of Neuroimmunology, 302, 2017. Crossref

  5. Boulay Anne- Cécile, Saubaméa Bruno, Adam Nicolas, Chasseigneaux Stéphanie, Mazaré Noémie, Gilbert Alice, Bahin Mathieu, Bastianelli Leïla, Blugeon Corinne, Perrin Sandrine, Pouch Juliette, Ducos Bertrand, Le Crom Stéphane, Genovesio Auguste, Chrétien Fabrice, Declèves Xavier, Laplanche Jean-Louis, Cohen-Salmon Martine, Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface, Cell Discovery, 3, 1, 2017. Crossref

  6. Smith Jayden A., Braga Alice, Verheyen Jeroen, Basilico Silvia, Bandiera Sara, Alfaro-Cervello Clara, Peruzzotti-Jametti Luca, Shu Dan, Haque Farzin, Guo Peixuan, Pluchino Stefano, RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity, Molecular Therapy - Nucleic Acids, 10, 2018. Crossref

  7. Boutej Hejer, Rahimian Reza, Thammisetty Sai Sampath, Béland Louis-Charles, Lalancette-Hébert Mélanie, Kriz Jasna, Diverging mRNA and Protein Networks in Activated Microglia Reveal SRSF3 Suppresses Translation of Highly Upregulated Innate Immune Transcripts, Cell Reports, 21, 11, 2017. Crossref

  8. Johnstone Maddison R, Sun Mujun, Taylor Caroline J, Brady Rhys D, Grills Brian L, Church Jarrod E, Shultz Sandy R, McDonald Stuart J, Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice, Brain Injury, 32, 2, 2018. Crossref

  9. Dekens Doortje W., Naudé Petrus J. W., Keijser Jan N., Boerema Ate S., De Deyn Peter P., Eisel Ulrich L. M., Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model, Journal of Neuroinflammation, 15, 1, 2018. Crossref

  10. Xu Huamin, Wang Youcui, Song Ning, Wang Jun, Jiang Hong, Xie Junxia, New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson’s Disease, Frontiers in Molecular Neuroscience, 10, 2018. Crossref

  11. Russell Nicholas H., Black Raiford T., Lee Nancy N., Doperalski Adele E., Reeves Thomas M., Phillips Linda L., Time-dependent hemeoxygenase-1, lipocalin-2 and ferritin induction after non-contusion traumatic brain injury, Brain Research, 1725, 2019. Crossref

  12. Ranjbar Taklimie Fatemeh, Gasterich Natalie, Scheld Miriam, Weiskirchen Ralf, Beyer Cordian, Clarner Tim, Zendedel Adib, Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke, International Journal of Molecular Sciences, 20, 6, 2019. Crossref

  13. De Kleijn Kim M. A., Martens Gerard J. M., Molecular Effects of FDA-Approved Multiple Sclerosis Drugs on Glial Cells and Neurons of the Central Nervous System, International Journal of Molecular Sciences, 21, 12, 2020. Crossref

  14. Cheng Ying-Ying, Ding Yin-Xiu, Bian Gan-Lan, Chen Liang-Wei, Yao Xin-Yi, Lin Ye-Bin, Wang Zhe, Chen Bei-Yu, Reactive Astrocytes Display Pro-inflammatory Adaptability with Modulation of Notch-PI3K-AKT Signaling Pathway Under Inflammatory Stimulation, Neuroscience, 440, 2020. Crossref

  15. Llorens Franc, Hermann Peter, Villar-Piqué Anna, Diaz-Lucena Daniela, Nägga Katarina, Hansson Oskar, Santana Isabel, Schmitz Matthias, Schmidt Christian, Varges Daniela, Goebel Stefan, Dumurgier Julien, Zetterberg Henrik, Blennow Kaj, Paquet Claire, Baldeiras Inês, Ferrer Isidro, Zerr Inga, Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia, Nature Communications, 11, 1, 2020. Crossref

  16. Petrozziello Tiziana, Mills Alexandra N., Farhan Sali M.K., Mueller Kaly A., Granucci Eric J., Glajch Kelly E., Chan James, Chew Sheena, Berry James D., Sadri‐Vakili Ghazaleh, Lipocalin‐2 is increased in amyotrophic lateral sclerosis, Muscle & Nerve, 62, 2, 2020. Crossref

  17. Zhang Jingwei, Novakovic Nemanja, Hua Ya, Keep Richard F., Xi Guohua, Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death, Experimental Neurology, 335, 2021. Crossref

  18. He Jingyi, Zhu Guofu, Wang Guoqing, Zhang Feng, Oxidative Stress and Neuroinflammation Potentiate Each Other to Promote Progression of Dopamine Neurodegeneration, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref

  19. Fulton Corey D.M., Beasley David W.C., Bente Dennis A., Dineley Kelly T., Long-term, West Nile virus-induced neurological changes: A comparison of patients and rodent models, Brain, Behavior, & Immunity - Health, 7, 2020. Crossref

  20. Ehinger Yann, Matagne Valerie, Cunin Valérie, Borloz Emilie, Seve Michel, Bourgoin-Voillard Sandrine, Borges-Correia Ana, Villard Laurent, Roux Jean-Christophe, Analysis of Astroglial Secretomic Profile in the Mecp2-Deficient Male Mouse Model of Rett Syndrome, International Journal of Molecular Sciences, 22, 9, 2021. Crossref

  21. Chen Xuebing, Qiu Feng, Zhao Xu, Lu Jiancong, Tan Xiaohui, Xu Jingtao, Chen Chuanxiang, Zhang Fu, Liu Chao, Qiao Dongfang, Wang Huijun, Astrocyte-Derived Lipocalin-2 Is Involved in Mitochondrion-Related Neuronal Apoptosis Induced by Methamphetamine, ACS Chemical Neuroscience, 11, 8, 2020. Crossref

  22. Li Fengwu, Geng Xiaokun, Yun Ho Jun, Haddad Yazeed, Chen Yuhua, Ding Yuchuan, Neuroplastic Effect of Exercise Through Astrocytes Activation and Cellular Crosstalk, Aging and disease, 12, 7, 2021. Crossref

  23. Dekens Doortje W., Eisel Ulrich L.M., Gouweleeuw Leonie, Schoemaker Regien G., De Deyn Peter P., Naudé Petrus J.W., Lipocalin 2 as a link between ageing, risk factor conditions and age-related brain diseases, Ageing Research Reviews, 70, 2021. Crossref

  24. Chen Yi-Hung, Xie Sheng-Yun, Chen Chao-Wei, Lu Dah-Yuu, Electroacupuncture improves repeated social defeat stress-elicited social avoidance and anxiety-like behaviors by reducing Lipocalin-2 in the hippocampus, Molecular Brain, 14, 1, 2021. Crossref

  25. Behrens Victoria, Voelz Clara, Müller Nina, Zhao Weiyi, Gasterich Natalie, Clarner Tim, Beyer Cordian, Zendedel Adib, Lipocalin 2 as a Putative Modulator of Local Inflammatory Processes in the Spinal Cord and Component of Organ Cross talk After Spinal Cord Injury, Molecular Neurobiology, 58, 11, 2021. Crossref

  26. Sonninen Tuuli-Maria, Hämäläinen Riikka H., Koskuvi Marja, Oksanen Minna, Shakirzyanova Anastasia, Wojciechowski Sara, Puttonen Katja, Naumenko Nikolay, Goldsteins Gundars, Laham-Karam Nihay, Lehtonen Marko, Tavi Pasi, Koistinaho Jari, Lehtonen Šárka, Metabolic alterations in Parkinson’s disease astrocytes, Scientific Reports, 10, 1, 2020. Crossref

  27. Wang Xuankang, Li Xin, Zuo Xiaoshuang, Liang Zhuowen, Ding Tan, Li Kun, Ma Yangguang, Li Penghui, Zhu Zhijie, Ju Cheng, Zhang Zhihao, Song Zhiwen, Quan Huilin, Zhang Jiawei, Hu Xueyu, Wang Zhe, Photobiomodulation inhibits the activation of neurotoxic microglia and astrocytes by inhibiting Lcn2/JAK2-STAT3 crosstalk after spinal cord injury in male rats, Journal of Neuroinflammation, 18, 1, 2021. Crossref

  28. Maysinger Dusica, Ji Jeff, Moquin Alexandre, Hossain Shireen, Hancock Mark A., Zhang Issan, Chang Philip K.Y., Rigby Matthew, Anthonisen Madeleine, Grütter Peter, Breitner John, McKinney R. Anne, Reimann Sabine, Haag Rainer, Multhaup Gerhard, Dendritic Polyglycerol Sulfates in the Prevention of Synaptic Loss and Mechanism of Action on Glia, ACS Chemical Neuroscience, 9, 2, 2018. Crossref

  29. Song Gyun Jee, Nam Youngpyo, Jo Myungjin, Jung Myungsu, Koo Ja Young, Cho Wansang, Koh Minseob, Park Seung Bum, Suk Kyoungho, A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype, Neuropharmacology, 109, 2016. Crossref

  30. Lazic Andrijana, Balint Vanda, Stanisavljevic Ninkovic Danijela, Peric Mina, Stevanovic Milena, Reactive and Senescent Astroglial Phenotypes as Hallmarks of Brain Pathologies, International Journal of Molecular Sciences, 23, 9, 2022. Crossref

  31. Hermann Peter, Villar-Piqué Anna, Schmitz Matthias, Schmidt Christian, Varges Daniela, Goebel Stefan, Bunck Timothy, Lindemann Hanna, Bogner Carla, Santana Isabel, Baldeiras Inês, Riggert Joachim, Zerr Inga, Llorens Franc, Plasma Lipocalin 2 in Alzheimer’s disease: potential utility in the differential diagnosis and relationship with other biomarkers, Alzheimer's Research & Therapy, 14, 1, 2022. Crossref

  32. Kalinin Sergey, Boullerne Anne I., Feinstein Douglas L., Serum levels of lipocalin-2 are elevated at early times in African American relapsing remitting multiple sclerosis patients, Journal of Neuroimmunology, 364, 2022. Crossref

  33. Tsai Cheng-Fang, Chen Guan-Wei, Chen Yen-Chang, Shen Ching-Kai, Lu Dah-Yuu, Yang Liang-Yo, Chen Jia-Hong, Yeh Wei-Lan, Regulatory Effects of Quercetin on M1/M2 Macrophage Polarization and Oxidative/Antioxidative Balance, Nutrients, 14, 1, 2021. Crossref

  34. Courbon Guillaume, David Valentin, Lipocalin-2: a novel link between the injured kidney and the bone, Current Opinion in Nephrology & Hypertension, 31, 4, 2022. Crossref

  35. Deng Yiming, Chen Duanduan, Gao Feng, Lv Hong, Zhang Guojun, Sun Xuan, Liu Lian, Mo Dapeng, Ma Ning, Song Ligang, Huo Xiaochuan, Yan Tianyi, Zhang Jingbo, Miao Zhongrong, Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via inhibition of LCN2, Journal of Biological Engineering, 13, 1, 2019. Crossref

  36. Peng Kang, Koduri Sravanthi, Ye Fenghui, Yang Jinting, Keep Richard F., Xi Guohua, Hua Ya, A timeline of oligodendrocyte death and proliferation following experimental subarachnoid hemorrhage, CNS Neuroscience & Therapeutics, 28, 6, 2022. Crossref

  37. Rissel René, Schaefer Moritz, Kamuf Jens, Ruemmler Robert, Riedel Julian, Mohnke Katja, Renz Miriam, Hartmann Erik K., Ziebart Alexander, Lung–brain ‘cross-talk’: systemic propagation of cytokines in the ARDS via the bloodstream using a blood transfusion model does not influence cerebral inflammatory response in pigs, PeerJ, 10, 2022. Crossref

  38. Li Qiang, Ru Xufang, Yang Yang, Zhao Hengli, Qu Jie, Chen Weixiang, Pan Pengyu, Ruan Huaizhen, Li Chaojun, Chen Yujie, Feng Hua, Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling, Neuroscience Bulletin, 2022. Crossref

  39. Stankiewicz Adrian M., Jaszczyk Aneta, Goscik Joanna, Juszczak Grzegorz R., Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 119, 2022. Crossref

  40. Gasterich Natalie, Bohn Amelie, Sesterhenn Anika, Nebelo Frederik, Fein Lena, Kaddatz Hannes, Nyamoya Stella, Kant Sebastian, Kipp Markus, Weiskirchen Ralf, Zendedel Adib, Beyer Cordian, Clarner Tim, Lipocalin 2 attenuates oligodendrocyte loss and immune cell infiltration in mouse models for multiple sclerosis, Glia, 70, 11, 2022. Crossref

  41. Zhang Jingwei, Wang Zeyu, Zhang Hao, Li Shuwang, Li Jing, Liu Hongwei, Cheng Quan, The role of lipocalin 2 in brain injury and recovery after ischemic and hemorrhagic stroke, Frontiers in Molecular Neuroscience, 15, 2022. Crossref

  42. Gorina Yana V., Salmina Alla B., Erofeev Alexander I, Gerasimov Evgeniy I., Bolshakova Anastasia V., Balaban Pavel M., Bezprozvanny Ilya B., Vlasova Olga L., Astrocyte Activation Markers, Biochemistry (Moscow), 87, 9, 2022. Crossref

  43. Araújo Bruna, Caridade-Silva Rita, Soares-Guedes Carla, Martins-Macedo Joana, Gomes Eduardo D., Monteiro Susana, Teixeira Fábio G., Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities, Cells, 11, 18, 2022. Crossref

  44. Yeh Wei-Lan, Huang Bor-Ren, Chen Guan-Wei, Charoensaensuk Vichuda, Tsai Cheng-Fang, Yang Liang-Yo, Lu Dah-Yuu, Chen Mao-Kai, Lin Chingju, Role of Zerumbone, a Phytochemical Sesquiterpenoid from Zingiber zerumbet Smith, in Maintaining Macrophage Polarization and Redox Homeostasis, Nutrients, 14, 24, 2022. Crossref

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