Searching journal content for Mitochondria (as phrase) in full text.

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RESEARCH PAPER: Tert-expressing cells contribute to salivary gland homeostasis and tissue regeneration after radiation therapy
- Li Guan,
- Vignesh Viswanathan,
- Yuyan Jiang,
- Sivakamasundari Vijayakumar,
- Hongbin Cao,
- Junfei Zhao,
- Deana Rae Crystal Colburg,
- Patrick Neuhöfer,
- Yiru Zhang,
- Jinglong Wang,
- Yu Xu,
- Eyiwunmi E. Laseinde,
- Rachel Hildebrand,
- Mobeen Rahman,
- Richard Frock,
- Christina Kong,
- Philip A. Beachy,
- Steven Artandi,
- and Quynh-Thu Le
Genes Dev. July 12, 2024 ; Published in Advance July 12, 2024, doi:10.1101/gad.351577.124
...studies have indicated that besides its canonical function, the catalytic unit of TERT has been found in the mitochondria, where it is involved in the detoxification of mitochondrial ROS and the maintenance of mitochondrial function upon DNA-damaging stress (DNAdamaging agents or radiation) in fibroblasts ...
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REVIEW: Glioblastoma microenvironment—from biology to therapy
- Renee D. Read,
- Zoe M. Tapp,
- Prajwal Rajappa,
- and Dolores Hambardzumyan
Genes Dev. May 29, 2024 ; Published in Advance May 29, 2024, doi:10.1101/gad.351427.123
...; Venkataramani et al. 2019; Venkatesh et al. 2019; Hausmann et al. 2023). Additionally, TMTs connect to nontumor astrocytes in the TME, which can transfer mitochondria to GSCs and vice versa, promotingmetabolic coadaptationofGSCs and theTME (Valdebenito et al. 2021; Watson et al. 2023). These coupling mechanisms ...
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RESEARCH PAPER: Intron lariat spliceosomes convert lariats to true circles: implications for intron transposition
- Manuel Ares, Jr.,
- Haller Igel,
- Sol Katzman,
- and John P. Donohue
Genes Dev. April 1, 2024 38: 322-335; Published in Advance May 9, 2024, doi:10.1101/gad.351764.124
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REVIEW: Pan-cellular organelles and suborganelles—from common functions to cellular diversity?
- Rico Schieweck and
- Magdalena Götz
Genes Dev. February 1, 2024 38: 98-114; Published in Advance March 14, 2024, doi:10.1101/gad.351337.123
..., translation, endocytosis, exocytosis, etc. Here we revisit the organelles involved in such common functions, reviewing recent evidence of unexpected differences of proteins at these organelles. For instance, centrosomes or mitochondria differ significantly in their protein composition in different, sometimes ...
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RESEARCH PAPER: Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regeneration
- Veronica Ciuffoli,
- Xuesong Feng,
- Kan Jiang,
- Natalia Acevedo-Luna,
- Kyung Dae Ko,
- A. Hong Jun Wang,
- Giulia Riparini,
- Mamduh Khateb,
- Brian Glancy,
- Stefania Dell'Orso,
- and Vittorio Sartorelli
Genes Dev. February 1, 2024 38: 151-167; Published in Advance March 7, 2024, doi:10.1101/gad.351428.123
...generates ATP and pyruvate, which is subsequently used by mitochondria for oxidative phosphorylation (Rodgers et al. 2014; Ryall et al. 2015b; Baker et al. 2022; Hong et al. 2022; Sousa-Victor et al. 2022; Zeng et al. 2022). Besides providing ATP, glycolysis generates glycolytic intermediates required ...
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OUTLOOK: A serine metabolic enzyme is flexing its muscle to help repair skeletal muscle
- Benjámin R. Baráth and
- Laszlo Nagy
Genes Dev. February 1, 2024 38: 95-97; Published in Advance March 14, 2024, doi:10.1101/gad.351666.124
...observations have been made for adult stem cells as well, such as skeletal muscle stem cells, which in their quiescent state have an SIRT1-activated PGC1 to promote FAO in the mitochondria. PGC1 activates OXPHOS genes and suppresses glycolysis, resulting in high levels of NAD+ and an active SIRT1 (Wu et al ...
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RESEARCH PAPER: A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks
- Yeon J. Lee and
- Donald C. Rio
Genes Dev. January 1, 2024 38: 11-30; Published in Advance January 5, 2024, doi:10.1101/gad.351104.123
...of the most abundant proteins in the hnRNPA1 immunoprecipitates based on normalized average intensity values. PHB is involved in cellular senescence. Together with PHB2, the prohibitin complex plays a role in the mitophagy receptor involved in targeting mitochondria for autophagic degradation (Wei et al. 2017 ...
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RESEARCH PAPER: The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels
- George A. Lemieux,
- Shinja Yoo,
- Lin Lin,
- Mihir Vohra,
- and Kaveh Ashrafi
Genes Dev. November/December 2023 37: 998-1016; Published in Advance December 13, 2023, doi:10.1101/gad.350745.123
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REVIEW: Mesenchymal stromal cells as conductors of adipose tissue remodeling
- Jessica Cannavino and
- Rana K. Gupta
Genes Dev. September 1, 2023 37: 781-800; Published in Advance October 5, 2023, doi:10.1101/gad.351069.123
...energy expenditure and nutrient homeostasis. BAT likely evolved in part as a mechanism for small mammals to defend against cold environmental temperatures. Brown adipocytes can be distinguished by their multilocular lipid droplet appearance and their abundance of mitochondria. In response to cold ...
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REVIEW: Metabolic partitioning in the brain and its hijacking by glioblastoma
- Jed de Ruiter Swain,
- Evdokia Michalopoulou,
- Evan K. Noch,
- Michael J. Lukey,
- and Linda Van Aelst
Genes Dev. August 1, 2023 37: 681-702; Published in Advance August 30, 2023, doi:10.1101/gad.350693.123
...and synaptic potentials (Magistretti and Allaman 2015). The vast majority of neuronal ATP is generated in mitochondria by oxidative phosphorylation (OXPHOS), and defects in this pathway are associated with a spectrum of neurological diseases (Breuer et al. 2013). A unique characteristic of brain metabolism ...

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