Loss of H3K27me3 expression is a highly sensitive marker for sporadic and radiation-induced MPNST
CN Prieto-Granada, T Wiesner… - The American journal …, 2016 - journals.lww.com
Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of
NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic
Ectoderm Development [EED] and Suppressor of Zeste 12 [SUZ12]). Mutations in EED and
SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent
aberrant transcriptional activation of polycomb repressive complex 2–repressed homeobox
master regulators. These findings prompted us to investigate the performance of an anti …
NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic
Ectoderm Development [EED] and Suppressor of Zeste 12 [SUZ12]). Mutations in EED and
SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent
aberrant transcriptional activation of polycomb repressive complex 2–repressed homeobox
master regulators. These findings prompted us to investigate the performance of an anti …