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Introduction Obesity had been considered a disease associated with behavior, an inappropriate consumption of food coupled with relative inactivity. Without a molecular mechanism to explain the pathology, obesity was merely a lack of willpower. The
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modulation ( Fig. 1 ), it is clear that this signalling pathway holds theoretical promise for the treatment of both type 2 diabetes mellitus (T2DM) and obesity, as has been witnessed to profound effect with GLP-1 ( Nauck et al. 2021 a ). This is especially
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Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
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Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA
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-fat high-sugar Western diet (WD) for 25 weeks and comprehensively characterized. We found that WD-fed Vil-FFA2 mice were protected from obesity and hyperglycemia; however, this effect was lost by the end of the study. Furthermore, the WD-fed Vil-FFA2 mice
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Introduction The worldwide incidence of obesity has rapidly escalated and shows little sign of diminution; in 2017 the World Obesity Federation (WOF) estimated that over 600 million individuals were classified as obese ( http
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Introduction Obesity is now a major health problem as it predisposes to insulin resistance, type 2 diabetes and cardiovascular malfunction. Although the pathogenesis of obesity and its associated co-morbidities are multifactorial, growing evidence
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA
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New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA
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New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA
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New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA
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New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA
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& Salvador 2000 , Al-Daghri et al. 2002 , Ceddia et al. 2002 ) and fertility ( Brann et al. 2002 , Moschos et al. 2002 ). Leptin null, Lep ob /Lep ob mice are obese, hyperphagic and insulin resistant ( Coleman 1978 ). Lipodystropic mice, lacking
Argentine Research Council (CONICET), La Plata, Buenos Aires, Argentina
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Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA
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Introduction Obesity results from an imbalance between energy intake and energy expenditure and represents a major threat to health across the globe. It is a chronic and multifactorial condition related to numerous diseases that often leads to
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Hospital Universitario Reina Sofia, Cordoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain
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Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
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Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Hospital Universitario Reina Sofia, Cordoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain
FiDiPro Program, Department of Physiology, University of Turku, Turku, Finland
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(MePD) of female rats, by selective infusion of a specific antagonist during the juvenile period, delayed puberty onset ( Adekunbi et al. 2017 ). Interestingly, this set of MePD Kiss1 neurons is sensitive to metabolic cues, so that maternal obesity
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia
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. 2016 , Sundaram & Yan 2016 , Woodie et al . 2018 ). TRF also reduced body weight and fasting glucose, improved glucose tolerance, reduced blood pressure and reduced atherogenic lipids in people with overweight and obesity ( Gill & Panda 2015
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Discovery of mutations in leptin and the leptin receptor in humans Early studies carried out in obese humans showed that leptin mRNA concentrations in adipose tissue and serum leptin concentrations correlated positively and very closely with the