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Alex M DePaoli NGM Biopharmaceuticals, Development, 630 Gateway Boulevard, South San Francisco, California 94080, USA

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Introduction Obesity had been considered a disease associated with behavior, an inappropriate consumption of food coupled with relative inactivity. Without a molecular mechanism to explain the pathology, obesity was merely a lack of willpower. The

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0258
Volume/Issue:
Volume 223: Issue 1
Free access
Ryan A Lafferty Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Peter R Flatt Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Victor A Gault Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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Nigel Irwin Diabetes Research Centre, Schools of Biomedical Sciences and Pharmacy & Pharmaceutical Sciences, Ulster University, Coleraine, Northern Ireland, UK

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modulation ( Fig. 1 ), it is clear that this signalling pathway holds theoretical promise for the treatment of both type 2 diabetes mellitus (T2DM) and obesity, as has been witnessed to profound effect with GLP-1 ( Nauck et al. 2021 a ). This is especially

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-23-0339
Volume/Issue:
Volume 262: Issue 2
Open access
Kristen R Lednovich Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sophie Gough Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Medha Priyadarshini Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Nupur Pandya Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Chioma Nnyamah Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Kai Xu Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Barton Wicksteed Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Sidharth Mishra USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Shalini Jain USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Joseph L Zapater Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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Jose Cordoba-Chacon Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

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Hariom Yadav USF Center for Microbiome Research, University of South Florida Morsani College of Medicine, Tampa, Florida, USA

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Brian T Layden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois, USA

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-fat high-sugar Western diet (WD) for 25 weeks and comprehensively characterized. We found that WD-fed Vil-FFA2 mice were protected from obesity and hyperglycemia; however, this effect was lost by the end of the study. Furthermore, the WD-fed Vil-FFA2 mice

Article Type:
Research Article
DOI:
https://doi.org/10.1530/JOE-23-0184
Volume/Issue:
Volume 260: Issue 2
Open access
John-Paul Fuller-Jackson
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Belinda A Henry Metabolism, Diabetes and Obesity Program, Monash Biomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, Victoria, Australia

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Introduction The worldwide incidence of obesity has rapidly escalated and shows little sign of diminution; in 2017 the World Obesity Federation (WOF) estimated that over 600 million individuals were classified as obese ( http

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0090
Volume/Issue:
Volume 237: Issue 3
Free access
T Mracek
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D Gao
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T Tzanavari
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Y Bao
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X Xiao
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C Stocker Obesity Biology Research Unit, Clore Laboratory, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK

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P Trayhurn
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C Bing
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Introduction Obesity is now a major health problem as it predisposes to insulin resistance, type 2 diabetes and cardiovascular malfunction. Although the pathogenesis of obesity and its associated co-morbidities are multifactorial, growing evidence

Article Type:
Research Article
DOI:
https://doi.org/10.1677/JOE-09-0299
Volume/Issue:
Volume 204: Issue 2
Open access
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Simon Klebanov The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Clinton M Astle The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Olga DeSimone The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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Vitaly Ablamunits The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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David E Harrison The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
New York Obesity Research Center, St Luke’s-Roosevelt Hospital Center, 1111 Amsterdam Avenue WH 1020, New York, New York 10025, USA

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& Salvador 2000 , Al-Daghri et al. 2002 , Ceddia et al. 2002 ) and fertility ( Brann et al. 2002 , Moschos et al. 2002 ). Leptin null, Lep ob /Lep ob mice are obese, hyperphagic and insulin resistant ( Coleman 1978 ). Lipodystropic mice, lacking

Article Type:
Research Article
DOI:
https://doi.org/10.1677/joe.1.06150
Volume/Issue:
Volume 186: Issue 1
Free access
María F Andreoli Laboratory of Experimental Neurodevelopment, Institute of Development and Paediatric Research (IDIP), La Plata Children’s Hospital and Scientific Research Commission, Province of Buenos Aires (CIC-PBA), La Plata, Buenos Aires, Argentina
Argentine Research Council (CONICET), La Plata, Buenos Aires, Argentina

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Jose Donato Jr Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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Isin Cakir Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA

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Mario Perello Laboratory of Neurophysiology, Multidisciplinary Institute of Cell Biology (IMBICE, Argentine Research Council (CONICET), National University of La Plata and Scientific Research Commission, Province of Buenos Aires (CIC-PBA)), La Plata, Buenos Aires, Argentina

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Introduction Obesity results from an imbalance between energy intake and energy expenditure and represents a major threat to health across the globe. It is a chronic and multifactorial condition related to numerous diseases that often leads to

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-18-0606
Volume/Issue:
Volume 241: Issue 3
Free access
M J Vazquez Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Hospital Universitario Reina Sofia, Cordoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain

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I Velasco Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain

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M Tena-Sempere Instituto Maimónides de Investigación Biomédica de Cordoba (IMIBIC), Cordoba, Spain
Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
Hospital Universitario Reina Sofia, Cordoba, Spain
CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Cordoba, Spain
FiDiPro Program, Department of Physiology, University of Turku, Turku, Finland

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(MePD) of female rats, by selective infusion of a specific antagonist during the juvenile period, delayed puberty onset ( Adekunbi et al. 2017 ). Interestingly, this set of MePD Kiss1 neurons is sensitive to metabolic cues, so that maternal obesity

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-19-0223
Volume/Issue:
Volume 242: Issue 2
Free access
Prashant Regmi Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia

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Rajesh Chaudhary Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia

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Amanda J Page Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia

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Amy T Hutchison Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia

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Andrew D Vincent Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia

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Bo Liu Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia

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Leonie Heilbronn Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia
Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia

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. 2016 , Sundaram & Yan 2016 , Woodie et al . 2018 ). TRF also reduced body weight and fasting glucose, improved glucose tolerance, reduced blood pressure and reduced atherogenic lipids in people with overweight and obesity ( Gill & Panda 2015

Article Type:
Research Article
Collections:
Top-cited articles of 2023
DOI:
https://doi.org/10.1530/JOE-20-0404
Volume/Issue:
Volume 248: Issue 1
Restricted access
I Sadaf Farooqi MRC Metabolic Diseases Unit, Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK

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Stephen O'Rahilly MRC Metabolic Diseases Unit, Metabolic Research Laboratories, Wellcome Trust–MRC Institute of Metabolic Science, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK

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Discovery of mutations in leptin and the leptin receptor in humans Early studies carried out in obese humans showed that leptin mRNA concentrations in adipose tissue and serum leptin concentrations correlated positively and very closely with the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/JOE-14-0480
Volume/Issue:
Volume 223: Issue 1
Free access
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