1Stem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea
2Korea National Stem Cell Bank, Chungcheongbuk-do, Republic of Korea
3Department of Chronic Diseases Convergence Research, Division of Intractable Diseases Research, Korea National Institute of Health, Osong Health Technology Administration Complex, Republic of Korea
4Department of Functional Genomics, Korea University of Science & Technology (UST), Daejeon, Republic of Korea
5Applied Molecular Virology Laboratory, Institute Pasteur Korea, Seongnam-si, Republic of Korea
6College of Pharmacy, Ajou University, Suwon, Republic of Korea
7School of Pharmacy, Sungkyunkwan University, Suwon, Republic of Korea
Abbreviations: ACTA, actin alpha 2; ALB, albumin; CCL, C-C motif chemokine ligand; COL1A1, collagen type Ⅰ alpha 1 chain; COL3A1, collagen type Ⅲ alpha 1 chain; dpi, days postinfection; ESC, embryonic stem cell; FA, fatty acid; iMAC, induced macrophage; Kp-LO, Kupffer-like cell-containing liver organoid; LO, liver organoid; LO + iMAC, iMAC cocultured liver organoid; MARCO, macrophage receptor with collagenous structure; PLIN2, perilipin 2; PPAR, peroxisome proliferator-activated receptor; scRNA-seq, single-cell RNA sequencing; SREBF, sterol regulatory element binding factor; VCL, vinculin; VSIG4, v-set and immunoglobulin domain-containing 4.
Jaeseo Lee and Dayeon Gil contributed equally to this work.
Correspondence Jung-Hyun Kim, College of Pharmacy, Ajou University, Suwon, 16499, Republic of Korea. Email: [email protected] Myung Jin Son, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea. Email: [email protected]
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