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    • Open Access

    Peer-reviewed

    Research Article

    Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

    • Nobuhiro Nakamoto,

      Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Hyosun Cho,

      Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Abraham Shaked,

      Affiliation Department of Surgery, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Kim Olthoff,

      Affiliation Department of Surgery, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Mary E. Valiga,

      Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Mary Kaminski,

      Affiliation Department of Surgery, Penn Liver Transplant Center, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Emma Gostick,

      Affiliation Department of Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, United Kingdom

      ⨯
    • David A. Price,

      Affiliation Department of Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, United Kingdom

      ⨯
    • Gordon J. Freeman,

      Affiliation Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America

      ⨯
    • E. John Wherry,

      Affiliation Immunology Program, The Wistar Institute, Philadelphia, Pennsylvania, United States of America

      ⨯
    • Kyong-Mi Chang

      kmchang@mail.med.upenn.edu

      Affiliations Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

      ⨯
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