Raut AS, Kalonia DS (2015) Opalescence in monoclonal antibody solutions and its correlation with intermolecular interactions in dilute and concentrated solutions. J Pharm Sci 104:1263–1274. https://doi.org/10.1002/jps.24326
Article
CAS
PubMed
Google Scholar
Neergaard MS, Kalonia DS, Parshad H et al (2013) Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass – prediction of viscosity through protein–protein interaction measurements. Eur J Pharm Sci 49:400–410. https://doi.org/10.1016/j.ejps.2013.04.019
Article
CAS
PubMed
Google Scholar
Connolly BD, Petry C, Yadav S et al (2012) Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameter. Biophys J 103:69–78. https://doi.org/10.1016/j.bpj.2012.04.047
Article
CAS
PubMed
PubMed Central
Google Scholar
Ghosh R, Calero-Rubio C, Saluja A, Roberts CJ (2016) Relating protein-protein interactions and aggregation rates from low to high concentrations. J Pharm Sci 105:1086–1096. https://doi.org/10.1016/j.xphs.2016.01.004
Article
CAS
PubMed
Google Scholar
George A, Wilson WW (1994) Predicting protein crystallization from a dilute solution property. Acta Crystallogr D Biol Crystallogr 50:361–365. https://doi.org/10.1107/S0907444994001216
Article
CAS
PubMed
Google Scholar
Dumetz AC, Chockla AM, Kaler EW, Lenhoff AM (2008) Effects of pH on protein-protein interactions and implications for protein phase behavior. Biochim Biophys Acta 1784:600–610. https://doi.org/10.1016/j.bbapap.2007.12.016
Article
CAS
PubMed
Google Scholar
Mason BD, Zhang L, Remmele RL, Zhang J (2011) Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid-liquid phase separation. J Pharm Sci 100:4587–4596. https://doi.org/10.1002/jps.22650
Article
CAS
PubMed
Google Scholar
Saluja A, Fesinmeyer RM, Hogan S et al (2010) Diffusion and sedimentation interaction parameters for measuring the second virial coefficient and their utility as predictors of protein aggregation. Biophys J 99:2657–2665. https://doi.org/10.1016/j.bpj.2010.08.020
Article
CAS
PubMed
PubMed Central
Google Scholar
Blanco MA, Sahin E, Li Y, Roberts CJ (2011) Reexamining protein-protein and protein-solvent interactions from Kirkwood-Buff analysis of light scattering in multi-component solutions. J Chem Phys 134:225103. https://doi.org/10.1063/1.3596726
Article
CAS
PubMed
PubMed Central
Google Scholar
Woldeyes MA, Calero-Rubio C, Furst EM, Roberts CJ (2017) Predicting protein interactions of concentrated globular protein solutions using colloidal models. J Phys Chem B 121:4756–4767. https://doi.org/10.1021/acs.jpcb.7b02183
Article
CAS
PubMed
Google Scholar
Scherer TM, Liu J, Shire SJ, Minton AP (2010) Intermolecular interactions of IgG1 monoclonal antibodies at high concentrations characterized by light scattering. J Phys Chem B 114:12948–12957. https://doi.org/10.1021/jp1028646
Article
CAS
PubMed
Google Scholar
Arzensek D, Kuzman D, Podgornik R et al (2015) Hofmeister effects in monoclonal antibody solution interactions. J Phys Chem B 119:10375–10389. https://doi.org/10.1021/acs.jpcb.5b02459
Article
CAS
PubMed
Google Scholar
Fine BM, Lomakin A, Ogun OO, Benedek GB (1996) Static structure factor and collective diffusion of globular proteins in concentrated aqueous solution. J Chem Phys 104:326–335. https://doi.org/10.1063/1.470904
Article
CAS
Google Scholar
Stradner A, Sedgwick H, Cardinaux F et al (2004) Equilibrium cluster formation in concentrated protein solutions and colloids. Nature 432:492–495. https://doi.org/10.1038/nature03109
Article
CAS
PubMed
Google Scholar
Berne BJ, Pecora R (2000) Dynamic light scattering with applications to chemistry, biology, and physics. Dover Publications, Mineola, NY
Google Scholar
Blanco MA, Perevozchikova T, Martorana V et al (2014) Protein-protein interactions in dilute to concentrated solutions: α-chymotrypsinogen in acidic conditions. J Phys Chem B 118:5817–5831. https://doi.org/10.1021/jp412301h
Article
CAS
PubMed
PubMed Central
Google Scholar
Frisken BJ (2001) Revisiting the method of cumulants for the analysis of dynamic light-scattering data. Appl Opt 40:4087–4091
Article
CAS
Google Scholar
Nägele G (1996) On the dynamics and structure of charge-stabilized suspensions. Phys Rep 272:215–372. https://doi.org/10.1016/0370-1573(95)00078-X
Article
Google Scholar
Fernández C, Minton AP (2009) Static light scattering from concentrated protein solutions II: experimental test of theory for protein mixtures and weakly self-associating proteins. Biophys J 96:1992–1998. https://doi.org/10.1016/j.bpj.2008.11.054
Article
CAS
PubMed
PubMed Central
Google Scholar
Attri AK, Minton AP (2005) Composition gradient static light scattering: a new technique for rapid detection and quantitative characterization of reversible macromolecular hetero-associations in solution. Anal Biochem 346:132–138. https://doi.org/10.1016/j.ab.2005.08.013
Article
CAS
PubMed
Google Scholar
Woldeyes MA, Qi W, Razinkov VI et al (2018) How well do low- and high-concentration protein interactions predict solution viscosities of monoclonal antibodies? J Pharm Sci. https://doi.org/10.1016/j.xphs.2018.07.007
Calero-Rubio C, Saluja A, Roberts CJ (2016) Coarse-grained antibody models for “weak” protein–protein interactions from low to high concentrations. J Phys Chem B 120:6592–6605. https://doi.org/10.1021/acs.jpcb.6b04907
Article
CAS
PubMed
Google Scholar
Calero-Rubio C, Ghosh R, Saluja A, Roberts CJ (2018) Predicting protein-protein interactions of concentrated antibody solutions using dilute solution data and coarse-grained molecular models. J Pharm Sci 107:1269–1281. https://doi.org/10.1016/j.xphs.2017.12.015
Article
CAS
PubMed
Google Scholar
Liu L, Randolph TW, Carpenter JF (2012) Particles shed from syringe filters and their effects on agitation-induced protein aggregation. J Pharm Sci 101:2952–2959. https://doi.org/10.1002/jps.23225
Article
CAS
PubMed
Google Scholar
Schärtl W (2007) Light scattering from polymer solutions and nanoparticle dispersions. Springer, Berlin
Google Scholar