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Osteoarthritis

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Abstract

Osteoarthritis is the most common form of arthritis and continues to increase in prevalence with the aging population. This degenerative disease process involves a complex interaction of several factors including inflammation, genetics, joint structure, mechanical stresses, and cellular processes. This chapter discusses the fundamental pathogenesis, clinical findings, and treatment modalities of osteoarthritis.

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References

  1. Lane NE, Brandt K, Hawker G, Peeva E, Schreyer E, Tsuji W, et al. OARSI-FDA initiative: defining the disease state of osteoarthritis. Osteoarthr Cartil. 2011;19(5):478–82.

    Article  CAS  Google Scholar 

  2. Loeser RF. Osteoarthritis year in review 2013: biology. Osteoarthr Cartil. 2013;21(10):1436–42.

    Article  CAS  Google Scholar 

  3. Liu-Bryan R, Terkeltaub R. Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 2015;11(1):35–44.

    Article  CAS  Google Scholar 

  4. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil. 2014;22(3):363–88.

    Article  CAS  Google Scholar 

  5. Hunter DJ. Focusing osteoarthritis management on modifiable risk factors and future therapeutic prospects. Ther Adv Musculoskelet Dis. 2009;1(1):35–47.

    Article  CAS  Google Scholar 

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Correspondence to Alan David Kaye .

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Bouley, E., Jones, M.R., Kaye, A.D. (2019). Osteoarthritis. In: Abd-Elsayed, A. (eds) Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-99124-5_257

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  • DOI: https://doi.org/10.1007/978-3-319-99124-5_257

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-99123-8

  • Online ISBN: 978-3-319-99124-5

  • eBook Packages: MedicineMedicine (R0)

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