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Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson’s disease with chronic pain

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Abstract

Background and Objective

There are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson’s disease (PD). In the study, we investigated the functional connectivity pattern of raphe nuclei in Parkinson’s disease with chronic pain (PDP) to uncover its possible pathophysiology.

Methods

Fifteen PDP, who suffered from pain, lasted longer than 3 months, sixteen Parkinson’s disease patients with no pain (nPDP) and eighteen matched normal health controls (NCs) were recruited. All subjects completed the King’s Parkinson’s Pain Scale (KPPS) besides Parkinson-related scale and demographics. We performed a seed-based resting-state analysis of functional magnetic resonance imaging to explore whole-brain functional connectivity of the raphe nuclei. Multiple regression model was used to explore the related factors of pain including disease duration, disease severity, Hamilton Depression Rating Scale, age, sex, levodopa equivalent dose and the strength of network functional connectivity.

Results

Compared with the nPDP, the PDP group showed stronger functional connectivity between raphe nuclei and pain-related brain regions, including parietal lobe, insular lobe, cingulum cortex and prefrontal cortex, and the functional connectivity values of those areas were significantly positively correlated with KPPS independent of the clinical variables. Compared with NCs, the combined PD groups showed decreased functional connectivity including prefrontal cortex and cingulum cortex.

Conclusions

Abnormal functional connectivity model of raphe nuclei may be partly involved in pathophysiological mechanism of pain in PD.

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Funding

This research was supported by the National Natural Science Foundation of China (No. 81871002, 81471334, 81100981) and the National Key Clinical Specialties Construction Program of China.

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Author notes

  1. Yalian Shen, Juan Wang, and Juan Peng contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China

    Yalian Shen, Juan Wang, Xiaolin Wu, Xiaocui Chen, Jinjin Liu, Min Wei, Dezhi Zou, Yu Han & Oumei Cheng

  2. Department of Neurology, Yubei District People’s Hospital, Chongqing, 401120, China

    Yalian Shen

  3. Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China

    Juan Peng & Anran Wang

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  1. Yalian Shen
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Correspondence to Anran Wang or Oumei Cheng.

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Shen, Y., Wang, J., Peng, J. et al. Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson’s disease with chronic pain. Neurol Sci 43, 3175–3185 (2022). https://doi.org/10.1007/s10072-022-05864-9

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