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The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation

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Abstract

Neuroinflammation is characterized by reactive microglia and astrocytes (collectively called gliosis) in the central nervous system and is considered as one of the main pathological hallmarks in different neurodegenerative diseases such as Alzheimer’s disease, age-related dementia, and multiple sclerosis. Upon activation, glia undergoes structural and morphological changes such as the microglial cells swell in size and astrocytes become bushy, which play both beneficial and detrimental roles. Hence, they are unable to perform the normal physiological role in brain immunity. Curcumin, a cytokine suppressive anti-inflammatory drug, has a high proven pre-clinical potency and efficacy to reverse chronic neuroinflammation by attenuating the activation and morphological changes that occur in the microglia and astrocytes. This review will highlight the recent findings on the tree structure changes of microglia and astrocytes in neuroinflammation and the effects of curcumin against the activation and morphology of glial cells.

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Authors and Affiliations

  1. RWJMS Institute for Neurological Therapeutics and Department of Neurology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ, USA

    Faheem Ullah

  2. School of Medicine, Western Sydney University, Penrith, NSW, Australia

    Rashmi Gamage & Erika Gyengesi

  3. Charles Perkins Centre, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia

    Monokesh K. Sen

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  1. Faheem Ullah
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  2. Rashmi Gamage
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  3. Monokesh K. Sen
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  4. Erika Gyengesi
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FU designed, drafted, and wrote the manuscript. RG wrote sections, edited and reviewed the manuscript and prepared Fig 1. MKS reviewed and edited the manuscript. EG supervised, advised, edited and reviewed the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Erika Gyengesi.

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Ullah, F., Gamage, R., Sen, M.K. et al. The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation. Neurochem Res 47, 813–824 (2022). https://doi.org/10.1007/s11064-021-03499-4

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