The latest version of the Conserved Domain Database contains 2,128 new or updated NCBI-curated domains and now mirrors Pfam version 32 as well as models from NCBIfams, a collection of protein family hidden Markov models (HMMs) for improving bacterial genome annotation. We have also added fine-grained classifications of the cupin and PBP1 superfamilies. You can find this updated content on the CDD FTP site. Read on for detailed release statistics.
Database statistics for CDD version 3.18:
| Models | Source |
| 59,807 | total models from all Source Databases |
| 16,068 | NCBI CDD curation effort |
| 183 | NCBIfams |
| 1,012 | SMART v6.0 |
| 17,919 | PFAM v32 |
| 4,871 | COGs v1.0 |
| 10,885 | NCBI Protein Clusters |
| 4,488 | TIGRFAM v15 |
| 59,807 | Total models from all Source Databases
Organized into 4,381 multi-model Superfamilies |
The Conserved Domain Database is a resource for the annotation of functional units in proteins. This collection of domain models includes a set curated by NCBI that utilizes 3D structure to provide insights into sequence/structure/function relationships.