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. 1973 Jun;134(2):515–521. doi: 10.1042/bj1340515

Metabolic alterations produced in the liver by chronic ethanol administration. Changes related to energetic parameters of the cell

J Bernstein 1, L Videla 1, Y Israel 1
PMCID: PMC1177838  PMID: 16742812

Abstract

1. Chronic ethanol administration to rats for 21–27 days increases the rate of O2 consumption as measured in liver slices. The extra respiration can be abolished by inhibition of the active transport of Na+ and K+. Dinitrophenol activates the respiratory rate in the liver of the treated animals only in the presence of ouabain. 2. Active (ouabain-sensitive) transport of 86Rb and (Na++K+)-stimulated adenosine triphosphatase activity were increased in the livers of the ethanol-treated animals. 3. Chronic ethanol administration also led to a decrease in the phosphorylation potential ([ATP]/[ADP][Pi]) in the liver cell owing to a decrease in [ATP] and an increase in [Pi]. 4. It is suggested that an increased sodium pump activity is responsible for the increased oxidative capacity and for the insensitivity to dinitrophenol observed in the livers of ethanol-treated animals.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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