Table 3.
Top 10 oligonucleotides with the largest absolute correlations with
Human tissue |
Yeast_random_hexamer |
Yeast_oligo(dT) |
Mouse tissue |
||||
---|---|---|---|---|---|---|---|
Motif | Corr | Motif | Corr | Motif | Corr | Motif | Corr |
ACT or AGT | −0.312 | ATA or TAT | −0.550 | ATA or TAT | −0.543 | AG or CT | −0.350 |
A or T | −0.311 | ATAA or TTAT | −0.507 | ATAA or TTAT | −0.495 | AGAG or CTCT | −0.349 |
TA | −0.310 | AATA or TATT | −0.495 | AATA or TATT | −0.488 | CAG or CTG | −0.347 |
TTTC or GAAA | −0.308 | TAAA or TTTA | −0.495 | TAAA or TTTA | −0.484 | CTC or GAG | −0.346 |
ATTC or GAAT | −0.308 | AT | −0.486 | AT | −0.474 | TC or GA | −0.342 |
TCA or TGA | −0.308 | AAAA or TTTT | −0.481 | AAAA or TTTT | −0.469 | TCTG or CAGA | −0.342 |
TAG or CTA | −0.308 | ATG or CAT | −0.478 | AAAT or ATTT | −0.462 | AGC or GCT | −0.341 |
AT | −0.307 | AAAT or ATTT | −0.473 | ATG or CAT | −0.462 | C or G | −0.340 |
TTCA or TGAA | −0.306 | ATTA or TAAT | −0.471 | ATTA or TAAT | −0.458 | TCC or GGA | −0.339 |
ACA or TGT | −0.306 | TA | −0.468 | TA | −0.458 | AGA or TCT | −0.339 |
Every possible oligonucleotide with length ≤6 was considered. The occurrences of the oligonucleotides and their reverse complementary counterparts were pooled together for each gene. The correlation between the log of the oligonucleotide frequency and was calculated and ranked based on the absolute value. For the human tissue data, the average
across the nine tissues was used. For the yeast data, the samples were prepared using random hexamer or oligo(dT) primers. For the mouse data, the average
across three tissues were used. The hydrolysis of RNA was performed before cDNA priming for the mouse data.