Figure 6. A central role for NHK-1 kinase in meiotic progression.
NHK-1 promotes nuclear reorganisation from a recombination phase to a post-recombination phase, including karyosome formation, synaptonemal complex disassembly and condensin loading. NHK-1 directly phosphorylates BAF that anchors meiotic chromosomes to the nuclear envelope. DSBs activate the meiotic recombination checkpoint that suppresses NHK-1 kinase to prevent nuclear reorganisation.