Figure 4. Effects of Co-Treatment with Doxorubicin and a mTOR Inhibitor. Panel A.
The sensitivities of MCF-7 and MCF7/ΔAkt-1(CA) cells to different doses of doxorubicin in presented. Panel B. The sensitivity of MCF-7 cells to different doses of doxorubicin is compared with the effects of doxorubicin and a suboptimal dose of 1 nM rapamycin. Panel C. The sensitivities of MCF-7 and MCF7/ΔAkt-1(CA) cells to different doses of doxorubicin and a suboptimal dose of 1 nM rapamycin in presented. The statistical significance was determined by the unpaired t test. Comparisons determined to be significant are indicated with (***). Panel A. The P value between doxorubicin treatment of MCF-7 and MCF7/ΔAkt-1(CA) cells was 0.0005.