Table 1.
The Papp values of the eight catechins with and without the treatment of MK-571 sodium salt hydrate (MK571). Each value was the average of three different samples; mean values with the same lowercase letters in the same column indicate no significant difference at a 0.05 level; * indicate Papp values (apical (AP) to basolateral (BL)) in the absence of MK571 are significantly different from that (AP to BL) in the presence of MK571 (p < 0.05); # indicates Papp values (BL to AP) in the absence of MK571 that are significantly different from that (BL to AP) in the presence of MK571 (p < 0.05). EC: (−)-epicatechin: C: (+)-catechin; EGC: (−)-epigallocatechin; GC: (+)-gallocatechin; ECG: (−)-epicatechin gallate; CG: (−)-catechin gallate; EGCG: (−)-epigallocatechin gallate; GCG: (−)-gallocatechin gallate.
| Transport in the Absence of MK571 (10−7 cm/s) | Efflux Ratio | Transport in the Presence of MK571 (10−7 cm/s) | Efflux Ratio | |||
|---|---|---|---|---|---|---|
| AP to BL | BL to AP | AP to BL | BL to AP | |||
| C | 1.56 ± 0.11 b | 26.18 ± 1.52 a | 16.74 | 3.97 ± 0.55 a,b,* | 5.33 ± 0.45 a,# | 1.34 |
| EC | 1.52 ± 0.17 b | 16.94 ± 1.63 b | 11.16 | 4.39 ± 0.45 a,* | 4.65 ± 0.53 b,# | 1.06 |
| CG | 1.39 ± 0.12 b | 6.51 ± 0.42 d | 4.68 | 2.85 ± 0.10 c,* | 3.85 ± 0.22 c,# | 1.35 |
| ECG | 1.38 ± 0.09 b | 3.87 ± 0.31 e | 2.82 | 2.63 ± 0.22 c,* | 2.72 ± 0.30 d,# | 1.04 |
| GC | 2.64 ± 0.21 a | 8.75 ± 0.28 c | 3.32 | 3.43 ± 0.08 b,c,* | 4.45 ± 0.46 b,# | 1.30 |
| EGC | 2.46 ± 0.10 a | 6.74 ± 0.62 d | 2.74 | 3.63 ± 0.35 b,* | 3.67 ± 0.13 c,# | 1.01 |
| GCG | 1.03 ± 0.21 c | 2.93 ± 0.13 e | 2.84 | 1.73 ± 0.16 d,* | 2.14 ± 0.16 e,# | 1.24 |
| EGCG | 0.93 ± 0.08 c | 2.57 ± 0.10 e | 2.75 | 1.89 ± 0.18 d,* | 1.98 ± 0.20 e,# | 1.05 |