"Pregnanolone/chemistry"[MeSH] - Search Results

Year	Number of Results
1975	3
1976	1
1977	2
1978	1
1979	6
1980	14
1981	15
1982	5
1983	4
1984	1
1985	2
1986	4
1987	2
1988	5
1989	2
1990	2
1991	5
1993	1
1994	4
1995	6
1996	9
1997	12
1998	5
1999	3
2000	20
2001	15
2002	7
2003	15
2004	11
2005	12
2006	13
2007	13
2008	11
2009	13
2010	12
2011	7
2012	9
2013	10
2014	15
2015	16
2016	9
2017	11
2018	13
2019	13
2020	9
2021	6
2022	4
2023	2
2024	4

1

A systematic review and meta-analysis on efficacy and safety of Ganaxolone in epilepsy.

Khan P, Saini S, Hussain S, Majid H, Gupta S, Agarwal N. Khan P, et al. Expert Opin Pharmacother. 2024 Apr;25(5):621-632. doi: 10.1080/14656566.2024.2342413. Epub 2024 Apr 17. Expert Opin Pharmacother. 2024. PMID: 38606458 Review.

2

Intravenous Ganaxolone: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability in Healthy Adults.

Gasior M, Husain A, Barra ME, Raja SM, MacLeod D, Guptill JT, Vaitkevicius H, Rybak E. Gasior M, et al. Clin Pharmacol Drug Dev. 2024 Mar;13(3):248-258. doi: 10.1002/cpdd.1365. Epub 2024 Jan 17. Clin Pharmacol Drug Dev. 2024. PMID: 38231434

3

Neurosteroids as Novel Anticonvulsants for Refractory Status Epilepticus and Medical Countermeasures for Nerve Agents: A 15-Year Journey to Bring Ganaxolone from Bench to Clinic.

Reddy DS. Reddy DS. J Pharmacol Exp Ther. 2024 Jan 17;388(2):273-300. doi: 10.1124/jpet.123.001816. J Pharmacol Exp Ther. 2024. PMID: 37977814 Free PMC article. Review.

4

Long-term treatment with ganaxolone for seizures associated with cyclin-dependent kinase-like 5 deficiency disorder: Two-year open-label extension follow-up.

Olson HE, Amin S, Bahi-Buisson N, Devinsky O, Marsh ED, Pestana-Knight E, Rajaraman RR, Aimetti AA, Rybak E, Kong F, Miller I, Hulihan J, Demarest S. Olson HE, et al. Epilepsia. 2024 Jan;65(1):37-45. doi: 10.1111/epi.17826. Epub 2023 Nov 29. Epilepsia. 2024. PMID: 37950390 Clinical Trial.

5

Effects of Pregnanolone Glutamate and Its Metabolites on GABA_A and NMDA Receptors and Zebrafish Behavior.

Abramova V, Leal Alvarado V, Hill M, Smejkalova T, Maly M, Vales K, Dittert I, Bozikova P, Kysilov B, Hrcka Krausova B, Vyklicky V, Balik A, Fili K, Korinek M, Chodounska H, Kudova E, Ciz D, Martinovic J, Cerny J, Bartunek P, Vyklicky L. Abramova V, et al. ACS Chem Neurosci. 2023 May 17;14(10):1870-1883. doi: 10.1021/acschemneuro.3c00131. Epub 2023 May 1. ACS Chem Neurosci. 2023. PMID: 37126803 Free PMC article.

6

Intravenous ganaxolone for the treatment of refractory status epilepticus: Results from an open-label, dose-finding, phase 2 trial.

Vaitkevicius H, Ramsay RE, Swisher CB, Husain AM, Aimetti A, Gasior M. Vaitkevicius H, et al. Epilepsia. 2022 Sep;63(9):2381-2391. doi: 10.1111/epi.17343. Epub 2022 Jul 10. Epilepsia. 2022. PMID: 35748707 Free PMC article. Clinical Trial.

7

Ganaxolone: First Approval.

Lamb YN. Lamb YN. Drugs. 2022 Jun;82(8):933-940. doi: 10.1007/s40265-022-01724-0. Drugs. 2022. PMID: 35596878 Review.

8

Safety and efficacy of ganaxolone in patients with CDKL5 deficiency disorder: results from the double-blind phase of a randomised, placebo-controlled, phase 3 trial.

Knight EMP, Amin S, Bahi-Buisson N, Benke TA, Cross JH, Demarest ST, Olson HE, Specchio N, Fleming TR, Aimetti AA, Gasior M, Devinsky O; Marigold Trial Group. Knight EMP, et al. Lancet Neurol. 2022 May;21(5):417-427. doi: 10.1016/S1474-4422(22)00077-1. Lancet Neurol. 2022. PMID: 35429480 Clinical Trial.

9

Neurosteroid Modulation of GABA_A Receptor Function by Independent Action at Multiple Specific Binding Sites.

Wang L, Covey DF, Akk G, Evers AS. Wang L, et al. Curr Neuropharmacol. 2022;20(5):886-890. doi: 10.2174/1570159X19666211202150041. Curr Neuropharmacol. 2022. PMID: 34856904 Free PMC article.

10

Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders.

Crombie GK, Palliser HK, Shaw JC, Hodgson DM, Walker DW, Hirst JJ. Crombie GK, et al. Psychoneuroendocrinology. 2021 Nov;133:105423. doi: 10.1016/j.psyneuen.2021.105423. Epub 2021 Sep 24. Psychoneuroendocrinology. 2021. PMID: 34601389

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