The basic mechanism for the electrical stimulation of the nervous system
- PMID: 10077317
- DOI: 10.1016/s0306-4522(98)00330-3
The basic mechanism for the electrical stimulation of the nervous system
Abstract
Neural signals can be generated or blocked by extracellular electrodes or magnetic coils. New results about artificial excitation are based on a compartmental model of a target neuron and its equivalent electrical network, as well as on the theory of the generalized activating function. The analysis shows that: (i) in most cases, the origin of artificial excitation is within the axon and the soma is much more difficult to excite; (ii) within the central nervous system, positive and negative threshold currents essentially depend on the position and orientation of the neurons relative to the applied electric field; (iii) in several cases, stimulation with positive currents is easier; and (iv) it should be possible to excite synaptic activity without the generation of propagating action potentials. Furthermore, the theory of the generalized activating function gives hints to understanding the blockage of neural activity.
Similar articles
-
Principles of electrical stimulation of neural tissue.Handb Clin Neurol. 2013;116:3-18. doi: 10.1016/B978-0-444-53497-2.00001-2. Handb Clin Neurol. 2013. PMID: 24112880 Review.
-
Sites of neuronal excitation by epiretinal electrical stimulation.IEEE Trans Neural Syst Rehabil Eng. 2006 Mar;14(1):5-13. doi: 10.1109/TNSRE.2006.870488. IEEE Trans Neural Syst Rehabil Eng. 2006. PMID: 16562626
-
Analysis of the electrical excitation of CNS neurons.IEEE Trans Biomed Eng. 1998 Jun;45(6):766-72. doi: 10.1109/10.678611. IEEE Trans Biomed Eng. 1998. PMID: 9609941
-
Mechanisms for electrical stimulation of excitable tissue.Crit Rev Biomed Eng. 1994;22(3-4):253-305. Crit Rev Biomed Eng. 1994. PMID: 8598130 Review.
-
Burst generation by electrically coupled network in the snail helisoma: analysis using computer simulation.Brain Res. 1978 Dec 29;159(2):331-49. doi: 10.1016/0006-8993(78)90539-5. Brain Res. 1978. PMID: 215269
Cited by
-
Effects of non-invasive cervical spinal cord neuromodulation by trans-spinal electrical stimulation on cortico-muscular descending patterns in upper extremity of chronic stroke.Front Bioeng Biotechnol. 2024 Mar 21;12:1372158. doi: 10.3389/fbioe.2024.1372158. eCollection 2024. Front Bioeng Biotechnol. 2024. PMID: 38576448 Free PMC article.
-
NRV: An open framework for in silico evaluation of peripheral nerve electrical stimulation strategies.bioRxiv [Preprint]. 2024 Jan 16:2024.01.15.575628. doi: 10.1101/2024.01.15.575628. bioRxiv. 2024. PMID: 38293181 Free PMC article. Preprint.
-
Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry.Brain Stimul. 2023 Nov-Dec;16(6):1776-1791. doi: 10.1016/j.brs.2023.11.018. Epub 2023 Dec 6. Brain Stimul. 2023. PMID: 38056825 Free PMC article.
-
An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model.Sci Rep. 2023 Sep 23;13(1):15924. doi: 10.1038/s41598-023-40547-1. Sci Rep. 2023. PMID: 37741821 Free PMC article.
-
Combined optogenetic and electrical stimulation of the sciatic nerve for selective control of sensory fibers.Front Neurosci. 2023 Jun 8;17:1190662. doi: 10.3389/fnins.2023.1190662. eCollection 2023. Front Neurosci. 2023. PMID: 37360169 Free PMC article.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources