Multiple myeloma and related disorders. Lessons from an animal model
- PMID: 10192877
Multiple myeloma and related disorders. Lessons from an animal model
Abstract
This short review of our own work presents two aspects of the studies on multiple myeloma (MM) in an animal model--the aging C57BL/KaLwRij mouse: 1. the immunological/biological aspect of the development of monoclonal B-cell proliferative disorders, the so-called monoclonal gammopathies (MG), and 2. the use of the mouse myeloma of the 5TMM lines for studies on the etiology/pathogenesis of MM and for developing new ways of treatment of this disease. Our research revealed that there are at least four major mechanisms in the development of MG. Many of the results were confirmed in clinical studies and lead to a new classification of MG according to their biology and possible pathogenesis. Most of MG can be classified into one of the following categories: 1. B-cell malignancies, 2. B-cell benign neoplasia, 3. MG due to an immunodeficiency with T/B cell imbalance, and 4. Antigen driven MG.
Similar articles
-
Aging and proliferative homeostasis: monoclonal gammopathies in mice and men.Lab Anim Sci. 1992 Apr;42(2):138-41. Lab Anim Sci. 1992. PMID: 1318444 Review. No abstract available.
-
Idiopathic paraproteinaemia. IV. The role of genetic factors in the development of monoclonal B cell proliferative disorders--a study in the ageing C57BL/KaLwRij and CBA/BrARij mouse radiation chimeras.Clin Exp Immunol. 1984 Oct;58(1):213-6. Clin Exp Immunol. 1984. PMID: 6383667 Free PMC article.
-
Immunoregulation and differentiation markers in monoclonal gammopathies.Acta Haematol. 1987;78 Suppl 1:50-5. doi: 10.1159/000205903. Acta Haematol. 1987. PMID: 3124450
-
[Study of cellular immunology in malignant and benign monoclonal gammapathies].Schweiz Med Wochenschr. 1976 Dec 11;106(50):1823-5. Schweiz Med Wochenschr. 1976. PMID: 1087754 French.
-
Current concepts on monoclonal gammopathies.Aust N Z J Med. 1992 Jun;22(3):291-302. doi: 10.1111/j.1445-5994.1992.tb02127.x. Aust N Z J Med. 1992. PMID: 1497556 Review.
Cited by
-
Parathyroid hormone receptor mediates the anti-myeloma effect of proteasome inhibitors.Bone. 2014 Apr;61:39-43. doi: 10.1016/j.bone.2013.12.025. Epub 2013 Dec 31. Bone. 2014. PMID: 24389365 Free PMC article.
-
A novel mouse model for multiple myeloma (MOPC315.BM) that allows noninvasive spatiotemporal detection of osteolytic disease.PLoS One. 2012;7(12):e51892. doi: 10.1371/journal.pone.0051892. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23284805 Free PMC article.
-
Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.PLoS One. 2012;7(11):e48871. doi: 10.1371/journal.pone.0048871. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23173040 Free PMC article.
-
Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma.Haematologica. 2010 Jan;95(1):163-7. doi: 10.3324/haematol.2009.006411. Epub 2009 Oct 14. Haematologica. 2010. PMID: 19833631 Free PMC article.
-
Multiple myeloma cancer stem cells.J Clin Oncol. 2008 Jun 10;26(17):2895-900. doi: 10.1200/JCO.2007.15.8428. J Clin Oncol. 2008. PMID: 18539970 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Other Literature Sources
Medical