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. 1999 Apr 9;284(5412):313-6.
doi: 10.1126/science.284.5412.313.

Limb and skin abnormalities in mice lacking IKKalpha

K Takeda  1 , O Takeuchi, T Tsujimura, S Itami, O Adachi, T Kawai, H Sanjo, K Yoshikawa, N Terada, S Akira
Affiliations

Limb and skin abnormalities in mice lacking IKKalpha

K Takeda et al. Science. .

Abstract

The gene encoding inhibitor of kappa B (IkappaB) kinase alpha (IKKalpha; also called IKK1) was disrupted by gene targeting. IKKalpha-deficient mice died perinatally. In IKKalpha-deficient fetuses, limb outgrowth was severely impaired despite unaffected skeletal development. The epidermal cells in IKKalpha-deficient fetuses were highly proliferative with dysregulated epidermal differentiation. In the basal layer, degradation of IkappaB and nuclear localization of nuclear factor kappa B (NF-kappaB) were not observed. Thus, IKKalpha is essential for NF-kappaB activation in the limb and skin during embryogenesis. In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine-induced activation of NF-kappaB.

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