Review
doi: 10.1016/s0962-8924(99)01519-6.
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
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- PMID: 10203785
- DOI: 10.1016/s0962-8924(99)01519-6
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Review
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
Trends Cell Biol.
1999 Apr.
Abstract
The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, including phosphatidylinositol (3,4,5)-trisphosphate, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signalling. This article discusses the function of PTEN and how this could be linked to its activity as a tumour suppressor.
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