PTEN: a tumour suppressor that functions as a phospholipid phosphatase
- PMID: 10203785
- DOI: 10.1016/s0962-8924(99)01519-6
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
Abstract
The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, including phosphatidylinositol (3,4,5)-trisphosphate, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signalling. This article discusses the function of PTEN and how this could be linked to its activity as a tumour suppressor.
Similar articles
-
Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.J Immunol. 2002 Nov 15;169(10):5441-50. doi: 10.4049/jimmunol.169.10.5441. J Immunol. 2002. PMID: 12421919
-
The tumour suppressor PTEN: involvement of a tumour suppressor candidate protein in PTEN turnover.Biochem Soc Trans. 2004 Apr;32(Pt 2):343-7. doi: 10.1042/bst0320343. Biochem Soc Trans. 2004. PMID: 15046605 Review.
-
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.Biochem J. 2001 Jul 15;357(Pt 2):427-35. doi: 10.1042/0264-6021:3570427. Biochem J. 2001. PMID: 11439092 Free PMC article.
-
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.Curr Biol. 1998 Oct 22;8(21):1195-8. doi: 10.1016/s0960-9822(07)00493-9. Curr Biol. 1998. PMID: 9799739
-
Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN.Biochem Soc Trans. 2001 Nov;29(Pt 6):846-51. doi: 10.1042/0300-5127:0290846. Biochem Soc Trans. 2001. PMID: 11709086 Review.
Cited by
-
Induction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor.Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2400935121. doi: 10.1073/pnas.2400935121. Epub 2024 Jul 24. Proc Natl Acad Sci U S A. 2024. PMID: 39047034
-
Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice.Geroscience. 2024 Apr;46(2):2653-2670. doi: 10.1007/s11357-023-01025-8. Epub 2023 Dec 19. Geroscience. 2024. PMID: 38114855 Free PMC article.
-
Epigenetic regulation in lung cancer.MedComm (2020). 2023 Oct 26;4(6):e401. doi: 10.1002/mco2.401. eCollection 2023 Dec. MedComm (2020). 2023. PMID: 37901797 Free PMC article. Review.
-
MiRNA-related metastasis in oral cancer: moving and shaking.Cancer Cell Int. 2023 Aug 27;23(1):182. doi: 10.1186/s12935-023-03022-5. Cancer Cell Int. 2023. PMID: 37635248 Free PMC article. Review.
-
Alteration of tumor suppressors changes the endometrial tumor spectrum.EMBO Mol Med. 2023 Oct 11;15(10):e18166. doi: 10.15252/emmm.202318166. Epub 2023 Aug 17. EMBO Mol Med. 2023. PMID: 37587857 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous