The association of latent Epstein-Barr virus infection with hydroa vacciniforme
- PMID: 10233328
- DOI: 10.1046/j.1365-2133.1999.02777.x
The association of latent Epstein-Barr virus infection with hydroa vacciniforme
Abstract
Patients with hydroa vacciniforme (HV)-like eruptions and malignant potential have been reported from Asia and Mexico, and those patients frequently had an associated latent Epstein-Barr virus (EBV) infection. In order to elucidate the association of latent EBV infection with HV, we studied six children with typical manifestations of HV by detection of EBV genes and EBV-related RNAs in biopsy specimens from cutaneous lesions. Cutaneous lesions of all six children with typical HV contained EBV-encoded small nuclear RNA (EBER)+ cells in 3-10% of the dermal infiltrates, whereas no Bam HI-H, l-fragment (BHLF) mRNA, or transcripts encoding EA-D antigen, were detected. No EBER + cells were detected in other inflammatory or benign lymphoproliferative skin disorders tested. Polymerase chain reaction amplification confirmed the presence of EBV DNA sequences in five of six biopsy specimens from the patients. Latent EBV infection is associated with the development of cutaneous lesions of HV.
Similar articles
-
Hydroa Vacciniforme and Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Spectrum of Disease Phenotypes Associated with Ultraviolet Irradiation and Chronic Epstein-Barr Virus Infection.Int J Mol Sci. 2020 Dec 7;21(23):9314. doi: 10.3390/ijms21239314. Int J Mol Sci. 2020. PMID: 33297336 Free PMC article. Review.
-
Hydroa vacciniforme: a distinctive form of Epstein-Barr virus-associated T-cell lymphoproliferative disorders.Eur J Dermatol. 2019 Feb 1;29(1):21-28. doi: 10.1684/ejd.2018.3490. Eur J Dermatol. 2019. PMID: 30998212 Review.
-
Hydroa vacciniforme and hydroa vacciniforme-like T-cell lymphoma: an uncommon event for transformation.J Cutan Pathol. 2016 Dec;43(12):1102-1111. doi: 10.1111/cup.12801. Epub 2016 Sep 9. J Cutan Pathol. 2016. PMID: 27531667
-
A novel, noninvasive diagnostic probe for hydroa vacciniforme and related disorders: detection of latency-associated Epstein-Barr virus transcripts in the crusts.J Microbiol Methods. 2007 Feb;68(2):403-7. doi: 10.1016/j.mimet.2006.09.025. Epub 2006 Dec 1. J Microbiol Methods. 2007. PMID: 17141343
-
Pathogenic link between hydroa vacciniforme and Epstein-Barr virus-associated hematologic disorders.Arch Dermatol. 2006 May;142(5):587-95. doi: 10.1001/archderm.142.5.587. Arch Dermatol. 2006. PMID: 16702496
Cited by
-
Hydroa Vacciniforme and Hydroa Vacciniforme-Like Lymphoproliferative Disorder: A Spectrum of Disease Phenotypes Associated with Ultraviolet Irradiation and Chronic Epstein-Barr Virus Infection.Int J Mol Sci. 2020 Dec 7;21(23):9314. doi: 10.3390/ijms21239314. Int J Mol Sci. 2020. PMID: 33297336 Free PMC article. Review.
-
Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting.Leuk Lymphoma. 2020 Apr;61(4):808-819. doi: 10.1080/10428194.2019.1699080. Epub 2019 Dec 13. Leuk Lymphoma. 2020. PMID: 31833428 Free PMC article. Review.
-
The Global Landscape of EBV-Associated Tumors.Front Oncol. 2019 Aug 6;9:713. doi: 10.3389/fonc.2019.00713. eCollection 2019. Front Oncol. 2019. PMID: 31448229 Free PMC article. Review.
-
Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases.Front Pediatr. 2019 Mar 15;7:71. doi: 10.3389/fped.2019.00071. eCollection 2019. Front Pediatr. 2019. PMID: 30931288 Free PMC article. Review.
-
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas.Blood. 2019 Apr 18;133(16):1703-1714. doi: 10.1182/blood-2018-11-881268. Epub 2019 Jan 11. Blood. 2019. PMID: 30635287 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous