Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity
- PMID: 10388558
- DOI: 10.1006/jmbi.1999.2865
Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity
Abstract
The conventional myosin motor proteins that drive mammalian skeletal and cardiac muscle contraction include eight sarcomeric myosin heavy chain (MyHC) isoforms. Six skeletal MyHCs are encoded by genes found in tightly linked clusters on human and mouse chromosomes 17 and 11, respectively. The full coding regions of only two out of six mammalian skeletal MyHCs had been sequenced prior to this work. In an effort to assess the extent of sequence diversity within the human MyHC family we present new full-length coding sequences corresponding to four additional human genes: MyHC-IIb, MyHC-extraocular, MyHC-IIa and MyHC-IIx/d. This represents the first opportunity to compare the full coding sequences of all eight sarcomeric MyHC isoforms within a vertebrate organism. Sequence variability has been analyzed in the context of available structure/function data with an emphasis on potential functional diversity within the family. Results indicate that functional diversity among MyHCs is likely to be accomplished by having small pockets of sequence diversity in an otherwise highly conserved molecule.
Copyright 1999 Academic Press.
Similar articles
-
The sarcomeric myosin heavy chain gene family in the dog: analysis of isoform diversity and comparison with other mammalian species.Genomics. 2007 Feb;89(2):224-36. doi: 10.1016/j.ygeno.2006.08.004. Epub 2006 Sep 20. Genomics. 2007. PMID: 16989978
-
A distinct subclass of mammalian striated myosins: structure and molecular evolution of "superfast" or masticatory myosin heavy chain.J Mol Evol. 2002 Nov;55(5):544-52. doi: 10.1007/s00239-002-2349-6. J Mol Evol. 2002. PMID: 12399928
-
Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family.Mol Biol Evol. 2002 Apr;19(4):375-93. doi: 10.1093/oxfordjournals.molbev.a004093. Mol Biol Evol. 2002. PMID: 11919279
-
Inactivation of myosin heavy chain genes in the mouse: diverse and unexpected phenotypes.Microsc Res Tech. 2000 Sep 15;50(6):492-9. doi: 10.1002/1097-0029(20000915)50:6<492::AID-JEMT6>3.0.CO;2-J. Microsc Res Tech. 2000. PMID: 10998638 Review.
-
The evolution of the chicken sarcomeric myosin heavy chain multigene family.Soc Gen Physiol Ser. 1994;49:129-39. Soc Gen Physiol Ser. 1994. PMID: 7939891 Review.
Cited by
-
Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.Int J Mol Sci. 2024 Apr 21;25(8):4546. doi: 10.3390/ijms25084546. Int J Mol Sci. 2024. PMID: 38674131 Free PMC article. Review.
-
Differences in Mechanical, Electrical and Calcium Transient Performance of the Isolated Right Atrial and Ventricular Myocardium of Guinea Pigs at Different Preloads (Lengths).Int J Mol Sci. 2023 Oct 24;24(21):15524. doi: 10.3390/ijms242115524. Int J Mol Sci. 2023. PMID: 37958508 Free PMC article.
-
Myofilament dysfunction in diastolic heart failure.Heart Fail Rev. 2024 Jan;29(1):79-93. doi: 10.1007/s10741-023-10352-z. Epub 2023 Oct 14. Heart Fail Rev. 2024. PMID: 37837495 Free PMC article. Review.
-
Expression of MyHC-15 and -2x in human muscle spindles: An immunohistochemical study.J Anat. 2023 Nov;243(5):826-841. doi: 10.1111/joa.13923. Epub 2023 Jul 7. J Anat. 2023. PMID: 37420120 Free PMC article.
-
Platelet formation and activation are influenced by neuronal guidance proteins.Front Immunol. 2023 Jun 15;14:1206906. doi: 10.3389/fimmu.2023.1206906. eCollection 2023. Front Immunol. 2023. PMID: 37398659 Free PMC article. Review.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions
Grants and funding
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
