Adding ischaemic hand exercise during occlusion of the brachial artery increases the flow-mediated vasodilation in ultrasound studies of endothelial function
- PMID: 10451786
- DOI: 10.1046/j.1365-2281.1999.00147.x
Adding ischaemic hand exercise during occlusion of the brachial artery increases the flow-mediated vasodilation in ultrasound studies of endothelial function
Abstract
A non-invasive method has been introduced to study endothelial function by evaluating flow-mediated, endothelium-dependent vasodilation of the brachial artery. One weakness of this method is that the post-occlusion vasodilation response is very small in subjects above the age of 60 years, which is a problem when quantifying endothelial dysfunction above this age. We have therefore evaluated whether a higher post-occlusion flow stimulus and a larger vasodilation response can be achieved by adding ischaemic hand exercise during the occlusion of the brachial artery. The subject population was men (n = 12), aged 60 years, free from cardiovascular disease. B-mode ultrasound images for the measurement of lumen diameter of the brachial artery were recorded before and after reactive hyperaemia induced by occlusion of the artery. Blood flow velocity was recorded intermittently using a Doppler technique. Hyperaemia was induced in two different ways: first by occlusion only and then by adding ischaemic hand exercise during the occlusion. The results showed that flow velocity was higher and the duration of flow increase was longer after ischaemic hand exercise compared with occlusion only. Two minutes after cuff pressure release, the increase in blood flow velocity was significantly higher after ischaemic hand work compared with occlusion only (P < 0.01). The corresponding maximal lumen diameters after cuff pressure release were 4.63 +/- 0.35 and 4.45 +/- 0.34 respectively (P < 0.01). The flow-mediated vasodilation increased significantly from 2.24 +/- 2.00% after occlusion only to 7.42 +/- 3.32% after occlusion plus ischaemic hand exercise (P < 0.01). In conclusion, this study showed that a maximal endothelial-dependent vasodilation was not achieved after occlusion only in these 60-year-old men. Adding ischaemic hand exercise may therefore be of value when quantifying endothelial dysfunction in this age group.
Similar articles
-
Can the measurement of brachial artery flow-mediated dilation be applied to the acute exercise model?Cardiovasc Ultrasound. 2007 Nov 26;5:45. doi: 10.1186/1476-7120-5-45. Cardiovasc Ultrasound. 2007. PMID: 18039389 Free PMC article. Review.
-
Detection of endothelial dysfunction with brachial artery ultrasound scanning.Am Heart J. 2003 Jun;145(6):943-51. doi: 10.1016/S0002-8703(03)00097-8. Am Heart J. 2003. PMID: 12796748 Review.
-
Endothelium-dependent flow-mediated vasodilatation, insulin resistance and the metabolic syndrome in 60-year-old men.J Intern Med. 2002 Oct;252(4):305-13. doi: 10.1046/j.1365-2796.2002.01036.x. J Intern Med. 2002. PMID: 12366603
-
Noninvasive assessment of endothelium-dependent flow-mediated dilation of the brachial artery.Vasc Med. 1997;2(2):87-92. doi: 10.1177/1358863X9700200203. Vasc Med. 1997. PMID: 9546961
-
The effects of age and gender on brachial artery endothelium-dependent vasoactivity are stimulus-dependent.Clin Cardiol. 1995 Aug;18(8):471-6. doi: 10.1002/clc.4960180810. Clin Cardiol. 1995. PMID: 7586766
Cited by
-
The effect of two different hand exercises on grip strength, forearm circumference, and vascular maturation in patients who underwent arteriovenous fistula surgery.Ann Rehabil Med. 2014 Oct;38(5):648-57. doi: 10.5535/arm.2014.38.5.648. Epub 2014 Oct 30. Ann Rehabil Med. 2014. PMID: 25379494 Free PMC article.
-
Can a combination of handgrip exercise and prolonged forearm occlusion elicit a maximal brachial artery FMD response?Eur J Appl Physiol. 2014 Jun;114(6):1297-307. doi: 10.1007/s00421-014-2859-0. Epub 2014 Mar 13. Eur J Appl Physiol. 2014. PMID: 24623066
-
Roles of nitric oxide and prostaglandins in the hyperemic response to a maximal metabolic stimulus: redundancy prevails.Eur J Appl Physiol. 2013 Jun;113(6):1449-56. doi: 10.1007/s00421-012-2570-y. Epub 2012 Dec 19. Eur J Appl Physiol. 2013. PMID: 23250568 Clinical Trial.
-
Ischemic exercise hyperemia in the human forearm: reproducibility and roles of adenosine and nitric oxide.Eur J Appl Physiol. 2012 Jun;112(6):2065-72. doi: 10.1007/s00421-011-2035-8. Epub 2011 Sep 27. Eur J Appl Physiol. 2012. PMID: 21947452
-
The effect of oral antioxidants on brachial artery flow-mediated dilation following 5 and 10 min of ischemia.Eur J Appl Physiol. 2009 Nov;107(4):445-53. doi: 10.1007/s00421-009-1147-x. Epub 2009 Aug 11. Eur J Appl Physiol. 2009. PMID: 19669786 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources