Clinical Trial
doi: 10.1007/BF00262630.
Orgotein (superoxide dismutase): a drug for the amelioration of radiation-induced side effects. A double-blind, placebo-controlled study in patients with bladder tumours
- PMID: 105443
- DOI: 10.1007/BF00262630
Item in Clipboard
Clinical Trial
Orgotein (superoxide dismutase): a drug for the amelioration of radiation-induced side effects. A double-blind, placebo-controlled study in patients with bladder tumours
Urol Res.
1978.
Abstract
Orgotein, the drug version of Cu-Zn superoxide dismutases is a new and safe anti-inflammatory agent. Animal experiments have shown that it does not interfere with the tumourolytic effects of radiation or chemotherapy. A double-blind, placebo-controlled study has demonstrated that orgotein injected after each daily irradiation session can be used safely and effectively to ameliorate or prevent the side effects due to high-energy radiation therapy (8,400 or 6,400 rads) of bladder tumours. Orgotein significantly reduced the signs and symptoms both in the bladder and the bowel, indicating that it provides a therapeutic regimen for control of these side effects, which to date could only be treated symptomatically.
Similar articles
-
Radiation Induced Cystitis and Proctitis - Prediction, Assessment and Management.Asian Pac J Cancer Prev. 2015;16(14):5589-94. doi: 10.7314/apjcp.2015.16.14.5589. Asian Pac J Cancer Prev. 2015. PMID: 26320421 Review.
-
[Non-surgical treatment of acute and late radiation proctitis].Rev Med Suisse. 2005 Jan 19;1(3):228, 230, 232-5. Rev Med Suisse. 2005. PMID: 15770817 Review. French.
-
Prevention of radioinduced cystitis by orgotein: a randomized study.Anticancer Res. 1996 Jul-Aug;16(4A):2025-8. Anticancer Res. 1996. PMID: 8712737 Clinical Trial.
-
Orgotein in radiation treatment of bladder cancer. A report on allergic reactions and lack of radioprotective effect.Acta Oncol. 1987;26(2):101-4. doi: 10.3109/02841868709091748. Acta Oncol. 1987. PMID: 2955799 Clinical Trial.
-
Orgotein efficacy in ameliorating side effects due to radiation therapy. I. Double-blind, placebo-controlled trial in patients with bladder tumors.Curr Ther Res Clin Exp. 1976 Feb;19(2):198-211. Curr Ther Res Clin Exp. 1976. PMID: 813958 Clinical Trial. No abstract available.
Cited by
-
The past, present, and future of enzyme-based therapies.Drug Discov Today. 2022 Jan;27(1):117-133. doi: 10.1016/j.drudis.2021.09.004. Epub 2021 Sep 16. Drug Discov Today. 2022. PMID: 34537332 Free PMC article. Review.
-
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.Nat Rev Drug Discov. 2021 Sep;20(9):689-709. doi: 10.1038/s41573-021-00233-1. Epub 2021 Jun 30. Nat Rev Drug Discov. 2021. PMID: 34194012 Free PMC article. Review.
-
Biology of Radiation-Induced Lung Injury.Semin Radiat Oncol. 2021 Apr;31(2):155-161. doi: 10.1016/j.semradonc.2020.11.006. Semin Radiat Oncol. 2021. PMID: 33610273 Free PMC article. Review.
-
A Review of Clinical Radioprotection and Chemoprotection for Oral Mucositis.Transl Oncol. 2018 Jun;11(3):771-778. doi: 10.1016/j.tranon.2018.03.014. Epub 2018 Apr 23. Transl Oncol. 2018. PMID: 29698934 Free PMC article. Review.
-
Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic cancers.Cochrane Database Syst Rev. 2018 Jan 23;1(1):CD012529. doi: 10.1002/14651858.CD012529.pub2. Cochrane Database Syst Rev. 2018. PMID: 29360138 Free PMC article. Review.
