doi: 10.1038/14046.
Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis
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- PMID: 10559962
- DOI: 10.1038/14046
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Activation of a meiotic checkpoint regulates translation of Gurken during Drosophila oogenesis
Nat Cell Biol.
1999 Oct.
Abstract
The genes okra and spindle-B act during meiosis in Drosophila to repair double-stranded DNA breaks (DSBs) associated with meiotic recombination. Unexpectedly, mutations in these genes cause dorsoventral patterning defects during oogenesis. These defects result from a failure to accumulate Gurken protein, which is required to initiate dorsoventral patterning during oogenesis. Here we find that the block in Gurken accumulation in the oocyte cytoplasm reflects activation of a meiotic checkpoint in response to the persistence of DSBs in the nucleus. We also show that Vasa is a target of this meiotic checkpoint, and so may mediate the checkpoint-dependent translational regulation of Gurken.
Comment in
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DNA repair and pattern formation come together.Nat Cell Biol. 1999 Oct;1(6):E150-2. doi: 10.1038/14103. Nat Cell Biol. 1999. PMID: 10559976 No abstract available.
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