Highly conserved antigen-presenting function of CD1d molecules
- PMID: 10602876
- DOI: 10.1007/s002510050590
Highly conserved antigen-presenting function of CD1d molecules
Abstract
The lack of polymorphism of nonclassical antigen-presenting molecules has led to the proposal that they may carry out some conserved and essential antigen-presenting function. Although this is a plausible hypothesis, the major histocompatibility complex has undergone dramatic expansions and contractions through evolution, and there is surprisingly little evidence for interspecies conservation of nonclassical class I molecules. The CD1d molecule, by contrast, shows an extremely high degree of functional conservation between mice and humans, with regard to its interaction with the relatively invariant TCRs that are expressed by NK T cells. This conservation for CD1d recognition is observed either in the absence of exogenous Ag or together with a lipoglycan antigen. The close functional and phenotypic conservation of NK T cells, in mammalian species separated by approximately 50 million years, suggests an essential role in the immune system for CD1d recognition by NK T cells.
Similar articles
-
A subset of NKT cells that lacks the NK1.1 marker, expresses CD1d molecules, and autopresents the alpha-galactosylceramide antigen.J Immunol. 2000 Nov 1;165(9):4917-26. doi: 10.4049/jimmunol.165.9.4917. J Immunol. 2000. PMID: 11046017
-
CD1d-mediated recognition of an alpha-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution.J Exp Med. 1998 Oct 19;188(8):1521-8. doi: 10.1084/jem.188.8.1521. J Exp Med. 1998. PMID: 9782129 Free PMC article.
-
The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR.J Immunol. 2006 Jun 15;176(12):7447-55. doi: 10.4049/jimmunol.176.12.7447. J Immunol. 2006. PMID: 16751390
-
Lipid antigen presentation in the immune system: lessons learned from CD1d knockout mice.Immunol Rev. 1999 Jun;169:31-44. doi: 10.1111/j.1600-065x.1999.tb01304.x. Immunol Rev. 1999. PMID: 10450506 Review.
-
The CD1 system: antigen-presenting molecules for T cell recognition of lipids and glycolipids.Annu Rev Immunol. 1999;17:297-329. doi: 10.1146/annurev.immunol.17.1.297. Annu Rev Immunol. 1999. PMID: 10358761 Review.
Cited by
-
Augmenting Granzyme B-Expressing NK Cells by Invariant NKT Ligand-Loaded APCs in Patients with Postoperative Early Stage Non-Small Cell Lung Cancer: Results of a Randomized Phase II Study.Immunohorizons. 2023 Jan 1;7(1):1-16. doi: 10.4049/immunohorizons.2200091. Immunohorizons. 2023. PMID: 36637516 Free PMC article. Clinical Trial.
-
NKT Cells Contribute to the Control of Microbial Infections.Front Cell Infect Microbiol. 2021 Sep 14;11:718350. doi: 10.3389/fcimb.2021.718350. eCollection 2021. Front Cell Infect Microbiol. 2021. PMID: 34595131 Free PMC article. Review.
-
Human invariant natural killer T cells promote tolerance by preferential apoptosis induction of conventional dendritic cells.Haematologica. 2022 Feb 1;107(2):427-436. doi: 10.3324/haematol.2020.267583. Haematologica. 2022. PMID: 33440919 Free PMC article.
-
Human CD4- invariant NKT lymphocytes regulate graft versus host disease.Oncoimmunology. 2018 Aug 23;7(11):e1470735. doi: 10.1080/2162402X.2018.1470735. eCollection 2018. Oncoimmunology. 2018. PMID: 30377560 Free PMC article.
-
Targeting Innate-Like T Cells in Tuberculosis.Front Immunol. 2016 Dec 21;7:594. doi: 10.3389/fimmu.2016.00594. eCollection 2016. Front Immunol. 2016. PMID: 28066410 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources