Redox sensing by prokaryotic transcription factors
- PMID: 10605928
- DOI: 10.1016/s0006-2952(99)00289-0
Redox sensing by prokaryotic transcription factors
Abstract
Prokaryotic cells employ redox-sensing transcription factors to detect elevated levels of reactive oxygen species and regulate expression of antioxidant genes. In Escherichia coli, two such transcription factors, OxyR and SoxR, have been well characterized. The OxyR protein contains a thiol-disulfide redox switch to sense hydrogen peroxide. The SoxR protein uses a 2Fe-2S cluster to sense superoxide generated by redox-cycling agents, as well as to sense nitric oxide. Both proteins are turned on and off with very fast kinetics (approximate minutes), allowing rapid cellular responses to oxidative stress. The mechanisms by which these and other prokaryotic proteins sense redox signals have provided useful paradigms for understanding redox signal transduction in eukaryotic cells.
Similar articles
-
Oxidative stress sensing by the iron-sulfur cluster in the transcription factor, SoxR.J Inorg Biochem. 2014 Apr;133:87-91. doi: 10.1016/j.jinorgbio.2013.11.008. Epub 2013 Nov 28. J Inorg Biochem. 2014. PMID: 24332474 Review.
-
Redox-operated genetic switches: the SoxR and OxyR transcription factors.Trends Biotechnol. 2001 Mar;19(3):109-14. doi: 10.1016/s0167-7799(00)01542-0. Trends Biotechnol. 2001. PMID: 11179804 Review.
-
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status.Proc Natl Acad Sci U S A. 1999 May 25;96(11):6161-5. doi: 10.1073/pnas.96.11.6161. Proc Natl Acad Sci U S A. 1999. PMID: 10339558 Free PMC article.
-
Activation of the OxyR transcription factor by reversible disulfide bond formation.Science. 1998 Mar 13;279(5357):1718-21. doi: 10.1126/science.279.5357.1718. Science. 1998. PMID: 9497290
-
Study of redox-regulated transcription factors in prokaryotes.Methods. 1997 Mar;11(3):267-78. doi: 10.1006/meth.1996.0421. Methods. 1997. PMID: 9073570
Cited by
-
Escherichia coli non-coding regulatory regions are highly conserved.NAR Genom Bioinform. 2024 May 20;6(2):lqae041. doi: 10.1093/nargab/lqae041. eCollection 2024 Jun. NAR Genom Bioinform. 2024. PMID: 38774514 Free PMC article.
-
The Trimeric Autotransporter Adhesin EmaA and Infective Endocarditis.Pathogens. 2024 Jan 23;13(2):99. doi: 10.3390/pathogens13020099. Pathogens. 2024. PMID: 38392837 Free PMC article. Review.
-
Malondialdehyde Serum Levels in Patients with Systemic Sclerosis Relate to Dyslipidemia and Low Ventricular Ejection Fraction.Antioxidants (Basel). 2023 Aug 25;12(9):1668. doi: 10.3390/antiox12091668. Antioxidants (Basel). 2023. PMID: 37759971 Free PMC article.
-
Novel mechanism of hydrogen peroxide for promoting efficient natamycin synthesis in Streptomyces.Microbiol Spectr. 2023 Sep 11;11(5):e0087923. doi: 10.1128/spectrum.00879-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 37695060 Free PMC article.
-
Manganese transporters regulate the resumption of replication in hydrogen peroxide-stressed Escherichia coli.Biometals. 2023 Dec;36(6):1361-1376. doi: 10.1007/s10534-023-00523-8. Epub 2023 Jul 26. Biometals. 2023. PMID: 37493920
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases