Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
- PMID: 10970791
- PMCID: PMC1221309
Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
Erratum in
- Biochem J 2001 Sep 15;358(Pt 3):791-2
Abstract
The GLUT9 gene encodes a cDNA which exhibits significant sequence similarity with members of the glucose transporter (GLUT) family. The gene is located on chromosome 9q34 and consists of 10 exons separated by short introns. The amino acid sequence deduced from its cDNA predicts 12 putative membrane-spanning helices and all the motifs (sugar-transporter signatures) that have previously been shown to be essential for transport activity. A striking characteristic of GLUT9 is the presence of two arginines in the putative helices 7 and 8 at positions where the organic anion transporters harbour basic residues. The next relative of GLUT9 is the glucose transporter GLUT8/GLUTX1 (44.8% amino acid identity with GLUT9). A 2.6-kb transcript of GLUT9 was detected in spleen, peripheral leucocytes and brain. Transfection of COS-7 cells with GLUT9 produced expression of a 46-kDa membrane protein which exhibited reconstitutable glucose-transport activity and low-affinity cytochalasin-B binding. It is concluded that GLUT9 is a novel member of the family of sugar-transport facilitators with a tissue-specific function.
Similar articles
-
Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9).Genomics. 2000 Jun 1;66(2):217-20. doi: 10.1006/geno.2000.6195. Genomics. 2000. PMID: 10860667
-
Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1.Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99. doi: 10.1006/mgme.2001.3212. Mol Genet Metab. 2001. PMID: 11592815
-
Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle.Biochem J. 2001 Oct 15;359(Pt 2):443-9. doi: 10.1042/0264-6021:3590443. Biochem J. 2001. PMID: 11583593 Free PMC article.
-
The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review).Mol Membr Biol. 2001 Oct-Dec;18(4):247-56. doi: 10.1080/09687680110090456. Mol Membr Biol. 2001. PMID: 11780753 Review.
-
Molecular mechanisms of sugar transport across mammalian and microbial cell membranes.Biotechnol Appl Biochem. 1990 Oct;12(5):512-6. Biotechnol Appl Biochem. 1990. PMID: 2288705 Review.
Cited by
-
Fatty Acid-Rich Extract from Holothuria atra for Hyperuricemia via Expressions Modulation of GLUT9a and GLUT9b in Rat Model.Molecules. 2023 May 9;28(10):3981. doi: 10.3390/molecules28103981. Molecules. 2023. PMID: 37241722 Free PMC article.
-
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer.Int J Mol Sci. 2023 Apr 12;24(8):7136. doi: 10.3390/ijms24087136. Int J Mol Sci. 2023. PMID: 37108300 Free PMC article.
-
Muscle-Specific Ablation of Glucose Transporter 1 (GLUT1) Does Not Impair Basal or Overload-Stimulated Skeletal Muscle Glucose Uptake.Biomolecules. 2022 Nov 23;12(12):1734. doi: 10.3390/biom12121734. Biomolecules. 2022. PMID: 36551162 Free PMC article.
-
Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.Int J Mol Sci. 2022 Aug 29;23(17):9798. doi: 10.3390/ijms23179798. Int J Mol Sci. 2022. PMID: 36077188 Free PMC article.
-
Dynamic glucose uptake, storage, and release by human microvascular endothelial cells.Mol Biol Cell. 2022 Oct 1;33(12):ar106. doi: 10.1091/mbc.E22-04-0146. Epub 2022 Aug 3. Mol Biol Cell. 2022. PMID: 35921166 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases