Moderate-intensity regular exercise decreases serum tumor necrosis factor-alpha and HbA1c levels in healthy women
- PMID: 11033992
- DOI: 10.1038/sj.ijo.0801373
Moderate-intensity regular exercise decreases serum tumor necrosis factor-alpha and HbA1c levels in healthy women
Abstract
Objective: To evaluate the effects of moderate-intensity regular exercise on serum levels of tumor necrosis factor-alpha (TNF-alpha) and glucose and lipid metabolism parameters.
Design: Longitudinal intervention study of a 5 month exercise training program (30-45 min/day, 4-5 days/week).
Subjects: Forty-one healthy Japanese women aged 41-69 y at baseline; 27 participants in the exercise program.
Measurements: Body mass index (BMI), waist-to-hip ratio (WHR), percentage body fat, and fasting levels for serum TNF-alpha, serum soluble TNF receptor p55 (TNF-RI) and TNF receptor p75 (TNF-RII), serum lipids, HbA1c, and serum insulin before and after exercise.
Results: In overweight to obese subjects, serum levels of TNF-alpha, TNF-RI and TNF-RII were significantly higher than those in lean subjects. There were significant correlations between log serum TNF-alpha and BMI, percentage body fat, WHR, HbA1c and log insulin. TNF-RI was significantly correlated with BMI, percentage body fat, WHR and HbA1c. TNF-RII was also associated with BMI, percentage body fat and WHR. However, the correlation between TNF-RII and HbA1c did not reach statistical significance. Neither TNF-RI nor TNF-RII was correlated with log insulin. In contrast, TNF-alpha, TNF-RI and TNF-RII were negatively correlated with HDL cholesterol. Regular exercise decreased BMI, percentage body fat, HbA1c, serum TNF-alpha, TNF-RI and TNF-RII and increased HDL cholesterol levels. In addition, exercise-induced change in serum TNF-alpha was independently correlated with changes in HbA1c and serum insulin, after being adjusted for the change in fat-free mass.
Conclusion: Changes in serum TNF-alpha that occur with exercise may play an important role in improving glucose metabolism parameters.
Similar articles
-
Serum concentrations of nitric oxide, tumor necrosis factor (TNF)-alpha and TNF soluble receptors in women with overweight and obesity.Metabolism. 2004 Oct;53(10):1268-73. doi: 10.1016/j.metabol.2004.07.001. Metabolism. 2004. PMID: 15375781 Clinical Trial.
-
Increased serum leptin concentrations correlate with soluble tumour necrosis factor receptor levels in patients with cirrhosis.Clin Endocrinol (Oxf). 2002 Dec;57(6):805-11. doi: 10.1046/j.1365-2265.2002.01672.x. Clin Endocrinol (Oxf). 2002. PMID: 12460331
-
Changes in tumor necrosis factor-alpha system and insulin sensitivity during an exercise training program in obese women with normal and impaired glucose tolerance.Eur J Endocrinol. 2001 Sep;145(3):273-80. doi: 10.1530/eje.0.1450273. Eur J Endocrinol. 2001. PMID: 11517007
-
Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects.Int J Obes Relat Metab Disord. 1999 Apr;23(4):355-60. doi: 10.1038/sj.ijo.0800826. Int J Obes Relat Metab Disord. 1999. PMID: 10340812
-
Soluble tumor necrosis factor receptors are elevated in relation to severity of congestive heart failure.Jpn Circ J. 1997 Aug;61(8):657-64. doi: 10.1253/jcj.61.657. Jpn Circ J. 1997. PMID: 9276770
Cited by
-
Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies.Exp Gerontol. 2024 Mar;187:112364. doi: 10.1016/j.exger.2024.112364. Epub 2024 Jan 25. Exp Gerontol. 2024. PMID: 38266886 Free PMC article.
-
The role of exercise and hypoxia on glucose transport and regulation.Eur J Appl Physiol. 2023 Jun;123(6):1147-1165. doi: 10.1007/s00421-023-05135-1. Epub 2023 Jan 23. Eur J Appl Physiol. 2023. PMID: 36690907 Free PMC article. Review.
-
Household Income Is Related to Dietary Fiber Intake and Dietary Acid Load in People with Type 2 Diabetes: A Cross-Sectional Study.Nutrients. 2022 Aug 7;14(15):3229. doi: 10.3390/nu14153229. Nutrients. 2022. PMID: 35956405 Free PMC article.
-
Protocol for a pilot randomized controlled trial of a mobile health exercise intervention for older patients with myeloid neoplasms (GO-EXCAP 2).J Geriatr Oncol. 2022 May;13(4):545-553. doi: 10.1016/j.jgo.2021.12.011. Epub 2021 Dec 21. J Geriatr Oncol. 2022. PMID: 34949540 Free PMC article.
-
Impact of Physical Activity and Weight Loss on Fat Mass, Glucose Metabolism, and Inflammation in Older African Americans with Osteoarthritis.Nutrients. 2020 Oct 28;12(11):3299. doi: 10.3390/nu12113299. Nutrients. 2020. PMID: 33126555 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Medical
Research Materials