Rel/NF-kappaB transcription factors: key mediators of B-cell activation
- PMID: 11043773
- DOI: 10.1034/j.1600-065x.2000.00615.x
Rel/NF-kappaB transcription factors: key mediators of B-cell activation
Abstract
The Rel/nuclear factor (NF)-kappaB family of transcription factors have been implicated in the regulation of a wide variety of genes, in particular those encoding proteins crucial to the function of the immune system. Through the use of mutant mice that lack one or more of these proteins, we have begun to examine the individual and combined roles of Rel, RelA and NF-kappaB1 in B-cell development and function. Here we outline and discuss how these transcription factors operate as differentiation stage-specific regulators of B-cell development, survival, division and immunoglobulin expression, emphasizing those Rel/NF-kappaB-regulated genes that mediate these functions.
Similar articles
-
Regulation of B-cell function by NF-kappaB c-Rel in health and disease.Cell Mol Life Sci. 2020 Sep;77(17):3325-3340. doi: 10.1007/s00018-020-03488-w. Epub 2020 Mar 4. Cell Mol Life Sci. 2020. PMID: 32130429 Free PMC article. Review.
-
Differential requirements for the canonical NF-κB transcription factors c-REL and RELA during the generation and activation of mature B cells.Immunol Cell Biol. 2017 Mar;95(3):261-271. doi: 10.1038/icb.2016.95. Epub 2016 Sep 21. Immunol Cell Biol. 2017. PMID: 27649781 Free PMC article.
-
B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells.J Exp Med. 1998 Mar 2;187(5):663-74. doi: 10.1084/jem.187.5.663. J Exp Med. 1998. PMID: 9480976 Free PMC article.
-
Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.J Exp Med. 2000 Apr 17;191(8):1281-92. doi: 10.1084/jem.191.8.1281. J Exp Med. 2000. PMID: 10770796 Free PMC article.
-
The role of Rel/NF-kappaB transcription factors in B lymphocyte survival.Semin Immunol. 2003 Jun;15(3):159-66. doi: 10.1016/s1044-5323(03)00036-8. Semin Immunol. 2003. PMID: 14563114 Review.
Cited by
-
Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance.Front Endocrinol (Lausanne). 2023 Sep 19;14:1232143. doi: 10.3389/fendo.2023.1232143. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37795356 Free PMC article.
-
Clinical and Molecular Properties of Human Immunodeficiency Virus-Related Diffuse Large B-Cell Lymphoma.Front Oncol. 2021 Apr 29;11:675353. doi: 10.3389/fonc.2021.675353. eCollection 2021. Front Oncol. 2021. PMID: 33996608 Free PMC article. Review.
-
Myeloid-Derived Suppressor Cell Differentiation in Cancer: Transcriptional Regulators and Enhanceosome-Mediated Mechanisms.Front Immunol. 2021 Jan 14;11:619253. doi: 10.3389/fimmu.2020.619253. eCollection 2020. Front Immunol. 2021. PMID: 33519825 Free PMC article. Review.
-
Regulation of B-cell function by NF-kappaB c-Rel in health and disease.Cell Mol Life Sci. 2020 Sep;77(17):3325-3340. doi: 10.1007/s00018-020-03488-w. Epub 2020 Mar 4. Cell Mol Life Sci. 2020. PMID: 32130429 Free PMC article. Review.
-
Regulation of NF-kB Signalling Through the PR55β-RelA Interaction in Osteoblasts.In Vivo. 2020 Mar-Apr;34(2):601-608. doi: 10.21873/invivo.11813. In Vivo. 2020. PMID: 32111759 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources