Review
doi: 10.1016/s0955-0674(00)00171-x.
The UNC-104/KIF1 family of kinesins
Affiliations
- PMID: 11163131
- DOI: 10.1016/s0955-0674(00)00171-x
Item in Clipboard
Review
The UNC-104/KIF1 family of kinesins
Curr Opin Cell Biol.
2001 Feb.
Abstract
Most UNC-104/KIF1 kinesins are monomeric motors that transport membrane-bounded organelles toward the plus ends of microtubules. Recent evidence implies that KIF1A, a synaptic vesicle motor, moves processively. This surprising behavior for a monomeric motor depends upon a lysine-rich loop in KIF1A that binds to the negatively charged carboxyl terminus of tubulin and, in the context of motor processivity, compensates for the lack of a second motor domain on the KIF1A holoenzyme.
Similar articles
-
Breathing down the neck of Unc104.J Cell Biol. 2003 Nov 24;163(4):693-5. doi: 10.1083/jcb.200310137. J Cell Biol. 2003. PMID: 14638852 Free PMC article. Review.
-
Kinesin motors and disease.Trends Cell Biol. 2002 Dec;12(12):585-91. doi: 10.1016/s0962-8924(02)02400-5. Trends Cell Biol. 2002. PMID: 12495847 Review.
-
Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.Science. 2002 Sep 27;297(5590):2263-7. doi: 10.1126/science.1073386. Science. 2002. PMID: 12351789
-
15 A resolution model of the monomeric kinesin motor, KIF1A.Cell. 2000 Jan 21;100(2):241-52. doi: 10.1016/s0092-8674(00)81562-7. Cell. 2000. PMID: 10660047
-
Reconstitution of membrane transport powered by a novel dimeric kinesin motor of the Unc104/KIF1A family purified from Dictyostelium.J Cell Biol. 1999 Nov 1;147(3):493-506. doi: 10.1083/jcb.147.3.493. J Cell Biol. 1999. PMID: 10545495 Free PMC article.
Cited by
-
Identifying mRNAs Residing in Myelinating Oligodendrocyte Processes as a Basis for Understanding Internode Autonomy.Life (Basel). 2023 Apr 4;13(4):945. doi: 10.3390/life13040945. Life (Basel). 2023. PMID: 37109474 Free PMC article.
-
KIF1A mediates axonal transport of BACE1 and identification of independently moving cargoes in living SCG neurons.Traffic. 2016 Nov;17(11):1155-1167. doi: 10.1111/tra.12428. Epub 2016 Oct 5. Traffic. 2016. PMID: 27484852 Free PMC article.
-
Myosin II does not contribute to wound repair in Dictyostelium cells.Biol Open. 2014 Sep 19;3(10):966-73. doi: 10.1242/bio.20149712. Biol Open. 2014. PMID: 25238760 Free PMC article.
-
CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits.Neuron. 2011 May 26;70(4):742-57. doi: 10.1016/j.neuron.2011.04.002. Neuron. 2011. PMID: 21609829 Free PMC article.
-
Hyphal growth: a tale of motors, lipids, and the Spitzenkörper.Eukaryot Cell. 2007 Mar;6(3):351-60. doi: 10.1128/EC.00381-06. Epub 2007 Jan 26. Eukaryot Cell. 2007. PMID: 17259546 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
