Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
- PMID: 11175850
- DOI: 10.1038/84643
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
Abstract
Metastasis of breast cancer occurs primarily through the lymphatic system, and the extent of lymph node involvement is a key prognostic factor for the disease. Whereas the significance of angiogenesis for tumor progression has been well documented, the ability of tumor cells to induce the growth of lymphatic vessels (lymphangiogenesis) and the presence of intratumoral lymphatic vessels have been controversial. Using a novel marker for lymphatic endothelium, LYVE-1, we demonstrate here the occurrence of intratumoral lymphangiogenesis within human breast cancers after orthotopic transplantation onto nude mice. Vascular endothelial growth factor (VEGF)-C overexpression in breast cancer cells potently increased intratumoral lymphangiogenesis, resulting in significantly enhanced metastasis to regional lymph nodes and to lungs. The degree of tumor lymphangiogenesis was highly correlated with the extent of lymph node and lung metastases. These results establish the occurrence and biological significance of intratumoral lymphangiogenesis in breast cancer and identify VEGF-C as a molecular link between tumor lymphangiogenesis and metastasis.
Comment in
-
From angiogenesis to lymphangiogenesis.Nat Med. 2001 Feb;7(2):151-2. doi: 10.1038/84579. Nat Med. 2001. PMID: 11175837 No abstract available.
Similar articles
-
Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma.Anat Rec (Hoboken). 2009 May;292(5):633-9. doi: 10.1002/ar.20893. Anat Rec (Hoboken). 2009. PMID: 19382240
-
Molecular control of lymphatic metastasis.Ann N Y Acad Sci. 2008;1131:225-34. doi: 10.1196/annals.1413.020. Ann N Y Acad Sci. 2008. PMID: 18519975 Review.
-
Tumor and lymph node lymphangiogenesis--impact on cancer metastasis.J Leukoc Biol. 2006 Oct;80(4):691-6. doi: 10.1189/jlb.1105653. Epub 2006 Jun 22. J Leukoc Biol. 2006. PMID: 16793912 Review.
-
Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2.Cancer Res. 2006 Mar 1;66(5):2650-7. doi: 10.1158/0008-5472.CAN-05-1843. Cancer Res. 2006. PMID: 16510584
-
Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.Cancer Res. 2005 Nov 1;65(21):9789-98. doi: 10.1158/0008-5472.CAN-05-0901. Cancer Res. 2005. PMID: 16267000
Cited by
-
Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma: A comprehensive review.World J Hepatol. 2024 Apr 27;16(4):537-549. doi: 10.4254/wjh.v16.i4.537. World J Hepatol. 2024. PMID: 38689749 Free PMC article. Review.
-
Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2317760121. doi: 10.1073/pnas.2317760121. Epub 2024 Apr 23. Proc Natl Acad Sci U S A. 2024. PMID: 38652741 Free PMC article.
-
Lymphatic vessels in the age of cancer immunotherapy.Nat Rev Cancer. 2024 Jun;24(6):363-381. doi: 10.1038/s41568-024-00681-y. Epub 2024 Apr 11. Nat Rev Cancer. 2024. PMID: 38605228 Review.
-
Exosomes promote pre-metastatic niche formation in colorectal cancer.Heliyon. 2024 Mar 7;10(6):e27572. doi: 10.1016/j.heliyon.2024.e27572. eCollection 2024 Mar 30. Heliyon. 2024. PMID: 38509970 Free PMC article. Review.
-
Quantitative multiplex immunohistochemistry reveals inter-patient lymphovascular and immune heterogeneity in primary cutaneous melanoma.Front Immunol. 2024 Feb 1;15:1328602. doi: 10.3389/fimmu.2024.1328602. eCollection 2024. Front Immunol. 2024. PMID: 38361951 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
