Signal transduction. How do cells sense oxygen?
- PMID: 11292863
- PMCID: PMC3040953
- DOI: 10.1126/science.1060849
Signal transduction. How do cells sense oxygen?
Abstract
How do organisms sense the amount of oxygen in the environment and respond appropriately when the amount of oxygen decreases (a condition called hypoxia)? In their Perspective, Zhu and Bunn discuss new findings (Ivan et al., Jaakkola et al.) that reveal how the HIF transcription factor, which switches on a group of hypoxia-response proteins, is itself regulated by changes in oxygen tension. The authors are in the Hematology Division of the Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. E-mail: zhu@calvin.bwh.harvard.edu, bunn@calvin.bwh.harvard.edu
Comment on
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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.Science. 2001 Apr 20;292(5516):468-72. doi: 10.1126/science.1059796. Epub 2001 Apr 5. Science. 2001. PMID: 11292861
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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing.Science. 2001 Apr 20;292(5516):464-8. doi: 10.1126/science.1059817. Epub 2001 Apr 5. Science. 2001. PMID: 11292862
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References
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- Ivan M, et al. Science. 2001 April 5; (10.1126/science.1059817). Include this information when citing this paper.
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Mammalian HIFα includes HIF-1α and its homolog HIF-2α (EPAS1), which has a more limited range of tissue expression. Other HIFα homologs have been reported but are not known to be regulated by oxygen-dependent degradation.
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