The cellular receptor for measles virus--elusive no more
- PMID: 11376478
- DOI: 10.1002/rmv.308
The cellular receptor for measles virus--elusive no more
Abstract
The identity of the measles virus receptor has been controversial. Several years ago CD46 was identified as a cellular receptor for the Edmonston strain of measles virus, but most clinical isolates of measles virus, which are most efficiently isolated in the marmoset B cell line B95a, cannot grow in many CD46+ cell lines. Although some researchers attributed it to post-entry block in viral replication, others believed that there is a receptor other than CD46 for wild-type measles viruses. A new study showed that human signalling lymphocytic activation molecule (SLAM; also known as CDw150) is a cellular receptor for measles virus, including the Edmonston strain. SLAM is expressed on lymphocytes and dendritic cells, and plays an important role in lymphocyte activation. The identification of SLAM as a measles virus receptor nicely explains the pathogenesis of measles virus infection.
Copyright 2001 John Wiley & Sons, Ltd.
Similar articles
-
Measles virus receptors and tropism.Jpn J Infect Dis. 2006 Feb;59(1):1-5. Jpn J Infect Dis. 2006. PMID: 16495625 Review.
-
Measles virus receptors: SLAM and CD46.Rev Med Virol. 2004 Jul-Aug;14(4):217-29. doi: 10.1002/rmv.430. Rev Med Virol. 2004. PMID: 15248250 Review.
-
Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor.J Virol. 2001 May;75(9):4399-401. doi: 10.1128/JVI.75.9.4399-4401.2001. J Virol. 2001. PMID: 11287589 Free PMC article.
-
CDw150(SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus.Virology. 2001 Jan 5;279(1):9-21. doi: 10.1006/viro.2000.0711. Virology. 2001. PMID: 11145884
-
SLAM (CDw150) is a cellular receptor for measles virus.Nature. 2000 Aug 24;406(6798):893-7. doi: 10.1038/35022579. Nature. 2000. PMID: 10972291
Cited by
-
Helical peptides with disordered regions for measles viruses provide new generalized insights into fusion inhibitors.iScience. 2024 Jan 17;27(2):108961. doi: 10.1016/j.isci.2024.108961. eCollection 2024 Feb 16. iScience. 2024. PMID: 38333694 Free PMC article.
-
Glioblastoma microenvironment and its reprogramming by oncolytic virotherapy.Front Cell Neurosci. 2022 Sep 9;16:819363. doi: 10.3389/fncel.2022.819363. eCollection 2022. Front Cell Neurosci. 2022. PMID: 36159398 Free PMC article. Review.
-
Oncolytic Virotherapy for the Treatment of Malignant Glioma.Neurotherapeutics. 2017 Apr;14(2):333-344. doi: 10.1007/s13311-017-0516-0. Neurotherapeutics. 2017. PMID: 28265902 Free PMC article. Review.
-
Inhibition of Rho-associated coiled-coil-forming kinase increases efficacy of measles virotherapy.Cancer Gene Ther. 2013 Nov;20(11):630-7. doi: 10.1038/cgt.2013.58. Epub 2013 Oct 25. Cancer Gene Ther. 2013. PMID: 24157925 Free PMC article.
-
Canine distemper virus infects canine keratinocytes and immune cells by using overlapping and distinct regions located on one side of the attachment protein.J Virol. 2011 Nov;85(21):11242-54. doi: 10.1128/JVI.05340-11. Epub 2011 Aug 17. J Virol. 2011. PMID: 21849439 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical