Review
doi: 10.1146/annurev.biochem.70.1.777.
Mechanisms of viral membrane fusion and its inhibition
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- PMID: 11395423
- DOI: 10.1146/annurev.biochem.70.1.777
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Review
Mechanisms of viral membrane fusion and its inhibition
Annu Rev Biochem.
2001.
Abstract
Viral envelope glycoproteins promote viral infection by mediating the fusion of the viral membrane with the host-cell membrane. Structural and biochemical studies of two viral glycoproteins, influenza hemagglutinin and HIV-1 envelope protein, have led to a common model for viral entry. The fusion mechanism involves a transient conformational species that can be targeted by therapeutic strategies. This mechanism of infectivity is likely utilized by a wide variety of enveloped viruses for which similar therapeutic interventions should be possible.
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