The future of hormesis: where do we go from here?
- PMID: 11504189
- DOI: 10.1080/20014091111901
The future of hormesis: where do we go from here?
Abstract
Although the occurrence of U-shaped dose responses in toxicology (i.e., hormetic effects) have been known for more than a century, the concept of hormesis has long been marginalized under the belief that such observations could be explained by a combination of poor study designs and normal variability. However, recent efforts have established that numerous highly reliable studies demonstrating hormetic effects exist and that such findings appear to be highly generalizable across species, endpoint measures, and class of agents assessed. In light of such a long and complicated history, and its significant biomedical/toxicological implications, this article explores the unique challenges that the concept of hormesis confronts in both the experimental and institutional domains with respect to assessing its scientific foundations and validity and the impediments to its intstitutional acceptance and use with society. This perspective is then immediately critiqued by five authors in subsequent articles.
Comment in
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Reflections on the future of hormesis.Crit Rev Toxicol. 2001 Jul;31(4-5):649-51. Crit Rev Toxicol. 2001. PMID: 11504190 No abstract available.
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Hormesis in biogerontology.Crit Rev Toxicol. 2001 Jul;31(4-5):663-4. doi: 10.1080/20014091111929. Crit Rev Toxicol. 2001. PMID: 11504194 No abstract available.
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Commentary on white paper the future of hormesis: where do we go from here? Edward J. Calabrese.Crit Rev Toxicol. 2001 Jul;31(4-5):665-7. doi: 10.1080/20014091111938. Crit Rev Toxicol. 2001. PMID: 11504195 No abstract available.
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