Accelerated substrate cycling: a new energy-wasting role for leptin in vivo
- PMID: 11788362
- DOI: 10.1152/ajpendo.00037.2001
Accelerated substrate cycling: a new energy-wasting role for leptin in vivo
Abstract
Simultaneous lipolysis and reesterification form the triacylglycerol/fatty acid (TAG/FA) cycle, a substrate cycle commonly used for thermogenesis. Its rate was measured in vivo by indirect calorimetry and continuous infusion of [2-(3)H]glycerol and [1-(14)C]palmitate, after injection of leptin or vehicle saline in rabbits. Leptin stimulated in vivo lipolysis from 9.66 +/- 0.62 to 14.78 +/- 0.93 micromol x kg(-1) x min(-1), the rate of appearance of FA from 20.69 +/- 2.14 to 29.03 +/- 3.03 micromol x kg(-1) x min(-1), and TAG/FA cycling from 24.82 +/- 1.73 to 37.09 +/- 2.49 micromol FA x kg(-1) x min(-1). This large increase in total cycling was caused by an 85% rise in primary cycling (reesterification without transit in the circulation) and accounted for 14% of the difference in metabolic rate between the controls and the leptin-treated animals. This study shows that leptin causes a strong activation of TAG/FA cycling, lipolysis, and FA oxidation, shifting fuel preference from carbohydrates to lipids. Therefore, the acceleration of substrate cycling is a new mechanism triggered by leptin to increase metabolic rate, besides the known induction of uncoupling proteins.
Similar articles
-
Extending food deprivation reverses the short-term lipolytic response to fasting: role of the triacylglycerol/fatty acid cycle.J Exp Biol. 2012 May 1;215(Pt 9):1484-90. doi: 10.1242/jeb.062992. J Exp Biol. 2012. PMID: 22496284
-
The Randle cycle revisited: a new head for an old hat.Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E578-91. doi: 10.1152/ajpendo.00093.2009. Epub 2009 Jun 16. Am J Physiol Endocrinol Metab. 2009. PMID: 19531645 Free PMC article. Review.
-
High-altitude acclimation increases the triacylglycerol/fatty acid cycle at rest and during exercise.Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E537-44. doi: 10.1152/ajpendo.2001.281.3.E537. Am J Physiol Endocrinol Metab. 2001. PMID: 11500309
-
The regulatory, informational, and immunomodulatory roles of fat fuels.Am J Clin Nutr. 1993 May;57(5 Suppl):738S-750S; discussion 750S-751S. doi: 10.1093/ajcn/57.5.738S. Am J Clin Nutr. 1993. PMID: 8475891 Review.
-
Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest.J Appl Physiol (1985). 1993 Jul;75(1):108-13. doi: 10.1152/jappl.1993.75.1.108. J Appl Physiol (1985). 1993. PMID: 8376256
Cited by
-
Lipid Droplets: A Cellular Organelle Vital for Thermogenesis.Int J Biol Sci. 2022 Oct 24;18(16):6176-6188. doi: 10.7150/ijbs.77051. eCollection 2022. Int J Biol Sci. 2022. PMID: 36439883 Free PMC article. Review.
-
Adipose Tissue Remodeling in Pathophysiology.Annu Rev Pathol. 2023 Jan 24;18:71-93. doi: 10.1146/annurev-pathol-042220-023633. Epub 2022 Sep 7. Annu Rev Pathol. 2023. PMID: 36070562 Free PMC article. Review.
-
Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.Mol Metab. 2022 Jul;61:101499. doi: 10.1016/j.molmet.2022.101499. Epub 2022 Apr 22. Mol Metab. 2022. PMID: 35470094 Free PMC article.
-
Uncoupling Protein-1 (UCP1) in the Adult Horse: Correlations with Body Weight, Rectal Temperature and Lipid Profile.Animals (Basel). 2021 Jun 20;11(6):1836. doi: 10.3390/ani11061836. Animals (Basel). 2021. PMID: 34202932 Free PMC article.
-
Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes.Lipids Health Dis. 2018 Mar 20;17(1):55. doi: 10.1186/s12944-018-0710-z. Lipids Health Dis. 2018. PMID: 29554895 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous