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. 2002 Apr;10(4):1057-62.
doi: 10.1016/s0968-0896(01)00377-7.

Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities

Yuan-Yuan Wang  1 , Kay-Hooi Khoo, Shui-Tein Chen, Chun-Cheng Lin, Chi-Huey Wong, Chun-Hung Lin
Affiliations

Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities

Yuan-Yuan Wang et al. Bioorg Med Chem. 2002 Apr.

Abstract

A fucose-containing glycoprotein fraction which stimulates spleen cell proliferation and cytokine expression has been identified from the water-soluble extract of Ganoderma lucidum. Proteomic analysis of mouse spleen cells treated with this glycoprotein fraction showed approximately 50% change of the proteome. Further studies on the activities of this glycoprotein fraction through selective proteolysis and glycosidic cleavage indicate that a fucose containing polysaccharide fraction is responsible for stimulating the expression of cytokines, especially IL-1, IL-2 and INF-gamma.

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