Review
doi: 10.1038/nrg732.
Establishment of vertebrate left-right asymmetry
Affiliations
- PMID: 11836504
- DOI: 10.1038/nrg732
Item in Clipboard
Review
Establishment of vertebrate left-right asymmetry
Nat Rev Genet.
2002 Feb.
Abstract
The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance.
Similar articles
-
A conserved role for the nodal signaling pathway in the establishment of dorso-ventral and left-right axes in deuterostomes.J Exp Zool B Mol Dev Evol. 2008 Jan 15;310(1):41-53. doi: 10.1002/jez.b.21121. J Exp Zool B Mol Dev Evol. 2008. PMID: 16838294 Review.
-
[Mechanisms for establishment of vertebrate left-right asymmetry].Tanpakushitsu Kakusan Koso. 2005 Nov;50(13):1609-19. Tanpakushitsu Kakusan Koso. 2005. PMID: 16277239 Review. Japanese. No abstract available.
-
Nodal activity in the node governs left-right asymmetry.Genes Dev. 2002 Sep 15;16(18):2339-44. doi: 10.1101/gad.1016202. Genes Dev. 2002. PMID: 12231623 Free PMC article.
-
Role of asymmetric signals in left-right patterning in the mouse.Am J Med Genet. 2001 Jul 15;101(4):324-7. Am J Med Genet. 2001. PMID: 11471154
-
Smad5 is essential for left-right asymmetry in mice.Dev Biol. 2000 Mar 1;219(1):71-8. doi: 10.1006/dbio.1999.9594. Dev Biol. 2000. PMID: 10677256
Cited by
-
[Clinical Characteristics Analysis of 1051 Cases of Cleft Lip With/Without Cleft Palate in the Ethnic Tibetan Population].Sichuan Da Xue Xue Bao Yi Xue Ban. 2024 Mar 20;55(2):397-402. doi: 10.12182/20240360203. Sichuan Da Xue Xue Bao Yi Xue Ban. 2024. PMID: 38645847 Free PMC article. Chinese.
-
Twisted-plywood-like tissue formation in vitro. Does curvature do the twist?PNAS Nexus. 2024 Mar 21;3(4):pgae121. doi: 10.1093/pnasnexus/pgae121. eCollection 2024 Apr. PNAS Nexus. 2024. PMID: 38590971 Free PMC article.
-
Translational control of furina by an RNA regulon is important for left-right patterning, heart morphogenesis and cardiac valve function.Development. 2023 Dec 1;150(23):dev201657. doi: 10.1242/dev.201657. Epub 2023 Nov 30. Development. 2023. PMID: 38032088 Free PMC article.
-
Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation.Nat Commun. 2023 Sep 14;14(1):5675. doi: 10.1038/s41467-023-41482-5. Nat Commun. 2023. PMID: 37709743 Free PMC article.
-
Characterization of the Caudal Ventral Tubercle in the Sixth Cervical Vertebra in Modern Equus ferus caballus.Animals (Basel). 2023 Jul 22;13(14):2384. doi: 10.3390/ani13142384. Animals (Basel). 2023. PMID: 37508161 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
