Review
doi: 10.1016/s0092-8674(02)00617-7.
Integrating mRNA processing with transcription
Affiliations
- PMID: 11909521
- DOI: 10.1016/s0092-8674(02)00617-7
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Review
Integrating mRNA processing with transcription
Cell.
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Free article
Abstract
The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.
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