Systematic identification of pathways that couple cell growth and division in yeast
- PMID: 12089449
- DOI: 10.1126/science.1070850
Systematic identification of pathways that couple cell growth and division in yeast
Abstract
Size homeostasis in budding yeast requires that cells grow to a critical size before commitment to division in the late prereplicative growth phase of the cell cycle, an event termed Start. We determined cell size distributions for the complete set of approximately 6000 Saccharomyces cerevisiae gene deletion strains and identified approximately 500 abnormally small (whi) or large (lge) mutants. Genetic analysis revealed a complex network of newly found factors that govern critical cell size at Start, the most potent of which were Sfp1, Sch9, Cdh1, Prs3, and Whi5. Ribosome biogenesis is intimately linked to cell size through Sfp1, a transcription factor that controls the expression of at least 60 genes implicated in ribosome assembly. Cell growth and division appear to be coupled by multiple conserved mechanisms.
Comment in
-
Cell biology. When wee meets whi.Science. 2002 Jul 19;297(5580):351-2. doi: 10.1126/science.1073042. Science. 2002. PMID: 12130772 No abstract available.
Similar articles
-
SFP1 is involved in cell size modulation in respiro-fermentative growth conditions.Yeast. 2005 Apr 15;22(5):385-99. doi: 10.1002/yea.1218. Yeast. 2005. PMID: 15806610
-
Ribosome synthesis meets the cell cycle.Curr Opin Microbiol. 2004 Dec;7(6):631-7. doi: 10.1016/j.mib.2004.10.007. Curr Opin Microbiol. 2004. PMID: 15556036 Review.
-
CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast.Cell. 2004 Jun 25;117(7):899-913. doi: 10.1016/j.cell.2004.05.024. Cell. 2004. PMID: 15210111
-
Cell biology. When wee meets whi.Science. 2002 Jul 19;297(5580):351-2. doi: 10.1126/science.1073042. Science. 2002. PMID: 12130772 No abstract available.
-
[The SSD1/SRK1/SSL1/MCS1 gene in growth regulation].Tanpakushitsu Kakusan Koso. 1994 Mar;39(4):327-34. Tanpakushitsu Kakusan Koso. 1994. PMID: 8165277 Review. Japanese. No abstract available.
Cited by
-
A conserved function of corepressors is to nucleate assembly of the transcriptional preinitiation complex.bioRxiv [Preprint]. 2024 Apr 1:2024.04.01.587599. doi: 10.1101/2024.04.01.587599. bioRxiv. 2024. PMID: 38617365 Free PMC article. Preprint.
-
An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of the Drosophila wing disc.bioRxiv [Preprint]. 2024 Mar 14:2024.03.14.585098. doi: 10.1101/2024.03.14.585098. bioRxiv. 2024. PMID: 38559130 Free PMC article. Preprint.
-
Physiological adventures in Candida albicans: farnesol and ubiquinones.Microbiol Mol Biol Rev. 2024 Mar 27;88(1):e0008122. doi: 10.1128/mmbr.00081-22. Epub 2024 Mar 4. Microbiol Mol Biol Rev. 2024. PMID: 38436263 Review.
-
Evidence for novel mechanisms that control cell-cycle entry and cell size.Mol Biol Cell. 2024 Apr 1;35(4):ar46. doi: 10.1091/mbc.E23-05-0174. Epub 2024 Jan 17. Mol Biol Cell. 2024. PMID: 38231863 Free PMC article.
-
Length control emerges from cytoskeletal network geometry.bioRxiv [Preprint]. 2023 Nov 29:2023.11.28.569063. doi: 10.1101/2023.11.28.569063. bioRxiv. 2023. PMID: 38076874 Free PMC article. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Miscellaneous