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. 2002 Jul 27;360(9329):310-2.
doi: 10.1016/S0140-6736(02)09522-3.

Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever

Tadeusz J Kochel  1 , Douglas M Watts, Scott B Halstead, Curtis G Hayes, Angelica Espinoza, Vidal Felices, Roxana Caceda, Christian T Bautista, Ysabel Montoya, Susan Douglas, Kevin L Russell
Affiliations

Effect of dengue-1 antibodies on American dengue-2 viral infection and dengue haemorrhagic fever

Tadeusz J Kochel et al. Lancet. .

Abstract

In Iquitos, Peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by American genotype dengue-2 (American dengue-2) virus. We assayed serum samples collected in Iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two American dengue-2 viruses, and two Asian dengue-2 viruses. Sera positive for the dengue-1 antibody neutralised dengue-1 viruses and American dengue-2 viruses much more effectively than Asian dengue-2 viruses. Neutralisation of American dengue-2 virus by sera positive for dengue-1 antibodies may account for the absence of dengue haemorrhagic fever in individuals infected with dengue-1 in 1990-91 followed by American dengue-2 virus in 1995 in Iquitos, Peru.

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