Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation
- PMID: 12354387
- DOI: 10.1016/s1074-7613(02)00388-6
Involvement of LOX-1 in dendritic cell-mediated antigen cross-presentation
Abstract
Some exogenous antigens, such as heat shock proteins or apoptotic bodies, gain access to the MHC class I processing pathway and initiate CTL responses, a process called cross-priming. To be efficient in vivo, this process requires endocytosis of the antigen by dendritic cells via receptors which remain unidentified. Here, we report that scavenger receptors are the main HSP binding structures on human dendritic cells and identify LOX-1 as one of these molecules. A neutralizing anti-LOX-1 mAb inhibits Hsp70 binding to dendritic cells and Hsp70-induced antigen cross-presentation. In vivo, to target LOX-1 with a tumor antigen using an anti-LOX-1 mAb induces antitumor immunity. Thus, the scavenger receptor LOX-1 is certainly a promising target for cancer immunotherapy.
Similar articles
-
Emerging roles for scavenger receptor SREC-I in immunity.Cytokine. 2015 Oct;75(2):256-60. doi: 10.1016/j.cyto.2015.02.009. Epub 2015 Mar 9. Cytokine. 2015. PMID: 25767073 Free PMC article. Review.
-
Lectin-like oxidized low-density lipoprotein receptor-1 delivers heat shock protein 60-fused antigen into the MHC class I presentation pathway.J Immunol. 2010 Aug 15;185(4):2306-13. doi: 10.4049/jimmunol.0903214. Epub 2010 Jul 14. J Immunol. 2010. PMID: 20631313
-
Scavenger receptors and heat-shock protein-mediated antigen cross-presentation.Biochem Soc Trans. 2004 Aug;32(Pt 4):633-5. doi: 10.1042/BST0320633. Biochem Soc Trans. 2004. PMID: 15270694
-
On cross-priming of MHC class I-specific CTL: rule or exception?Eur J Immunol. 2002 Sep;32(9):2385-92. doi: 10.1002/1521-4141(200209)32:9<2385::AID-IMMU2385>3.0.CO;2-V. Eur J Immunol. 2002. PMID: 12207322 Review. No abstract available.
-
A retrogen strategy for presentation of an intracellular tumor antigen as an exogenous antigen by dendritic cells induces potent antitumor T helper and CTL responses.Cancer Res. 2001 Jan 1;61(1):197-205. Cancer Res. 2001. PMID: 11196161
Cited by
-
Diversity of extracellular HSP70 in cancer: advancing from a molecular biomarker to a novel therapeutic target.Front Oncol. 2024 Apr 5;14:1388999. doi: 10.3389/fonc.2024.1388999. eCollection 2024. Front Oncol. 2024. PMID: 38646439 Free PMC article. Review.
-
Effect of acupuncture therapy on vaccine-induced immune response in d-galactose-induced aging rats.Heliyon. 2023 Nov 19;9(12):e22645. doi: 10.1016/j.heliyon.2023.e22645. eCollection 2023 Dec. Heliyon. 2023. PMID: 38213597 Free PMC article.
-
Innate Immune Pathways in Atherosclerosis-From Signaling to Long-Term Epigenetic Reprogramming.Cells. 2023 Sep 26;12(19):2359. doi: 10.3390/cells12192359. Cells. 2023. PMID: 37830572 Free PMC article. Review.
-
Cell-targeted vaccines: implications for adaptive immunity.Front Immunol. 2023 Aug 16;14:1221008. doi: 10.3389/fimmu.2023.1221008. eCollection 2023. Front Immunol. 2023. PMID: 37662903 Free PMC article. Review.
-
Molecular Chaperone Receptors: An Update.Methods Mol Biol. 2023;2693:193-208. doi: 10.1007/978-1-0716-3342-7_15. Methods Mol Biol. 2023. PMID: 37540436
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials