Extinction antagonizes olfactory memory at the subcellular level
- PMID: 12372288
- DOI: 10.1016/s0896-6273(02)00832-2
Extinction antagonizes olfactory memory at the subcellular level
Abstract
Memory loss occurs by diverse mechanisms, as different time constants of performance decrement and sensitivities to experimental manipulations suggest. While the phenomena of memory decay, interference, and extinction are well established behaviorally, little is known about them at the circuit or molecular level. In Drosophila, odorant memories lasting up to 3 hr can be localized to mushroom body Kenyon cells, a single neuronal level in the olfactory pathway. The plasticity underlying this memory trace can be induced without Kenyon cell synaptic output. Experimental extinction, i.e., presentation of the conditioned stimulus without the reinforcer, reduces memory performance and does so at the same circuit level as memory formation. Thus, unreinforced presentation of learned odorants antagonizes intracellularly the signaling cascade underlying memory formation.
Comment in
-
Forgetting those painful moments.Neuron. 2002 Aug 29;35(5):815-7. doi: 10.1016/s0896-6273(02)00865-6. Neuron. 2002. PMID: 12372275
Similar articles
-
Presynaptic developmental plasticity allows robust sparse wiring of the Drosophila mushroom body.Elife. 2020 Jan 8;9:e52278. doi: 10.7554/eLife.52278. Elife. 2020. PMID: 31913123 Free PMC article.
-
Short neuropeptide F acts as a functional neuromodulator for olfactory memory in Kenyon cells of Drosophila mushroom bodies.J Neurosci. 2013 Mar 20;33(12):5340-5. doi: 10.1523/JNEUROSCI.2287-12.2013. J Neurosci. 2013. PMID: 23516298 Free PMC article.
-
Drosophila larvae establish appetitive olfactory memories via mushroom body neurons of embryonic origin.J Neurosci. 2010 Aug 11;30(32):10655-66. doi: 10.1523/JNEUROSCI.1281-10.2010. J Neurosci. 2010. PMID: 20702697 Free PMC article.
-
An engram found? Evaluating the evidence from fruit flies.Curr Opin Neurobiol. 2004 Dec;14(6):737-44. doi: 10.1016/j.conb.2004.10.014. Curr Opin Neurobiol. 2004. PMID: 15582377 Review.
-
Mushroom body memoir: from maps to models.Nat Rev Neurosci. 2003 Apr;4(4):266-75. doi: 10.1038/nrn1074. Nat Rev Neurosci. 2003. PMID: 12671643 Review. No abstract available.
Cited by
-
Prediction error drives associative learning and conditioned behavior in a spiking model of Drosophila larva.iScience. 2023 Dec 26;27(1):108640. doi: 10.1016/j.isci.2023.108640. eCollection 2024 Jan 19. iScience. 2023. PMID: 38292165 Free PMC article.
-
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila.Elife. 2022 Oct 17;11:e80445. doi: 10.7554/eLife.80445. Elife. 2022. PMID: 36250621 Free PMC article.
-
A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females.Elife. 2022 Sep 21;11:e77643. doi: 10.7554/eLife.77643. Elife. 2022. PMID: 36129174 Free PMC article.
-
Neural Circuits Underlying Behavioral Flexibility: Insights From Drosophila.Front Behav Neurosci. 2022 Jan 6;15:821680. doi: 10.3389/fnbeh.2021.821680. eCollection 2021. Front Behav Neurosci. 2022. PMID: 35069145 Free PMC article. Review.
-
Switch-like and persistent memory formation in individual Drosophila larvae.Elife. 2021 Oct 12;10:e70317. doi: 10.7554/eLife.70317. Elife. 2021. PMID: 34636720 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
