Regulating the actin cytoskeleton during vesicular transport
- PMID: 12383793
- DOI: 10.1016/s0955-0674(02)00349-6
Regulating the actin cytoskeleton during vesicular transport
Abstract
Although the actin cytoskeleton is widely believed to play an important role in intracellular protein transport, this role is poorly understood. Recently, progress has been made toward identifying specific actin-binding proteins and signaling molecules involved in regulating actin structures that function in the secretory pathway. Studies on coat protomer I (COPI)-mediated transport at the Golgi apparatus and on clathrin-mediated endocytosis have been particularly informative in identifying such mechanisms. Important similarities between actin regulation at the Golgi and at the plasma membrane have been uncovered. The studies reveal that ADP-ribosylation factor and vesicle coat proteins are able to act through the Rho-family GTP-binding proteins, Cdc42 and Rac, and several specific actin-binding proteins to direct actin assembly through the Arp2/3 complex. Efficient function of the secretory pathway is likely to require precise temporal regulation among transport-vesicle assembly, vesicle scission, and the targeting machinery. It is proposed that numerous actin regulatory mechanisms and the connections between actin signaling and vesicle-coat formation are employed to provide such temporal regulation.
Similar articles
-
Regulation of actin cytoskeleton dynamics by Arf-family GTPases.Trends Cell Biol. 2008 Apr;18(4):184-92. doi: 10.1016/j.tcb.2008.02.002. Epub 2008 Mar 6. Trends Cell Biol. 2008. PMID: 18328709 Free PMC article. Review.
-
Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1.Mol Biol Cell. 2002 Feb;13(2):621-31. doi: 10.1091/mbc.01-11-0547. Mol Biol Cell. 2002. PMID: 11854417 Free PMC article.
-
Molecular basis for coupling the plasma membrane to the actin cytoskeleton during clathrin-mediated endocytosis.Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2533-42. doi: 10.1073/pnas.1207011109. Epub 2012 Aug 27. Proc Natl Acad Sci U S A. 2012. PMID: 22927393 Free PMC article.
-
In vivo dynamics of clathrin and its adaptor-dependent recruitment to the actin-based endocytic machinery in yeast.Dev Cell. 2005 Jul;9(1):87-98. doi: 10.1016/j.devcel.2005.04.014. Dev Cell. 2005. PMID: 15992543
-
Regulating cytoskeleton-based vesicle motility.FEBS Lett. 2007 May 22;581(11):2112-8. doi: 10.1016/j.febslet.2007.01.094. Epub 2007 Feb 20. FEBS Lett. 2007. PMID: 17335816 Free PMC article. Review.
Cited by
-
Arp2/3-dependent endocytosis ensures Cdc42 oscillations by removing Pak1-mediated negative feedback.J Cell Biol. 2024 Sep 2;223(10):e202311139. doi: 10.1083/jcb.202311139. Epub 2024 Jul 16. J Cell Biol. 2024. PMID: 39012625 Free PMC article.
-
The Arp2/3 complex promotes periodic removal of Pak1-mediated negative feedback to facilitate anticorrelated Cdc42 oscillations.bioRxiv [Preprint]. 2023 Nov 9:2023.11.08.566261. doi: 10.1101/2023.11.08.566261. bioRxiv. 2023. PMID: 38106068 Free PMC article. Preprint.
-
Branched Actin Maintains Acetylated Microtubule Network in the Early Secretory Pathway.Cells. 2021 Dec 22;11(1):15. doi: 10.3390/cells11010015. Cells. 2021. PMID: 35011578 Free PMC article.
-
Cross-talk between clathrin-dependent post-Golgi trafficking and clathrin-mediated endocytosis in Arabidopsis root cells.Plant Cell. 2021 Sep 24;33(9):3057-3075. doi: 10.1093/plcell/koab180. Plant Cell. 2021. PMID: 34240193 Free PMC article.
-
Methylthioadenosine (MTA) boosts cell-specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression.FEBS Open Bio. 2020 Dec;10(12):2791-2804. doi: 10.1002/2211-5463.13019. Epub 2020 Nov 11. FEBS Open Bio. 2020. PMID: 33128321 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous