Positive and negative selection of T cells
- PMID: 12414722
- DOI: 10.1146/annurev.immunol.21.120601.141107
Positive and negative selection of T cells
Abstract
A functional immune system requires the selection of T lymphocytes expressing receptors that are major histocompatibility complex restricted but tolerant to self-antigens. This selection occurs predominantly in the thymus, where lymphocyte precursors first assemble a surface receptor. In this review we summarize the current state of the field regarding the natural ligands and molecular factors required for positive and negative selection and discuss a model for how these disparate outcomes can be signaled via the same receptor. We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated.
Similar articles
-
Low-affinity peptides and T-cell selection.Trends Immunol. 2009 Feb;30(2):53-60. doi: 10.1016/j.it.2008.11.004. Epub 2009 Feb 7. Trends Immunol. 2009. PMID: 19201651 Review.
-
Apoptotic signal transduction and T cell tolerance.Autoimmunity. 2007 Sep;40(6):442-52. doi: 10.1080/08916930701464962. Autoimmunity. 2007. PMID: 17729038 Review.
-
Influence of the affinity of selecting ligands on T cell positive and negative selection and the functional maturity of the positively selected T cells.Crit Rev Immunol. 1997;17(5-6):399-410. Crit Rev Immunol. 1997. PMID: 9419427 Review.
-
Differences in the avidity of TCR interactions with a superantigenic ligand affect negative selection but do not allow positive selection.J Immunol. 1995 Dec 1;155(11):5115-23. J Immunol. 1995. PMID: 7594520
-
Modeling positive and negative selection and differentiation processes in the thymus.J Theor Biol. 1995 Jul 7;175(1):103-26. doi: 10.1006/jtbi.1995.0124. J Theor Biol. 1995. PMID: 7564390
Cited by
-
Legacy of the discovery of the T-cell receptor: 40 years of shaping basic immunology and translational work to develop novel therapies.Cell Mol Immunol. 2024 Jul;21(7):790-797. doi: 10.1038/s41423-024-01168-4. Epub 2024 May 31. Cell Mol Immunol. 2024. PMID: 38822079 Free PMC article. No abstract available.
-
Intracellular cytokines in peritoneal leukocytes relate to lifespan in aging and long-lived female mice.Biogerontology. 2024 May 15. doi: 10.1007/s10522-024-10110-0. Online ahead of print. Biogerontology. 2024. PMID: 38748335
-
Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance.Cell Rep. 2024 Apr 23;43(4):114072. doi: 10.1016/j.celrep.2024.114072. Epub 2024 Apr 5. Cell Rep. 2024. PMID: 38581680 Free PMC article.
-
Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis.Front Immunol. 2024 Mar 20;15:1339714. doi: 10.3389/fimmu.2024.1339714. eCollection 2024. Front Immunol. 2024. PMID: 38571951 Free PMC article. Review.
-
Mechanism study of ubiquitination in T cell development and autoimmune disease.Front Immunol. 2024 Mar 18;15:1359933. doi: 10.3389/fimmu.2024.1359933. eCollection 2024. Front Immunol. 2024. PMID: 38562929 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
