doi: 10.1103/PhysRevLett.89.198101.
Epub 2002 Oct 16.
Conduction block in one-dimensional heart fibers
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- PMID: 12443153
- DOI: 10.1103/PhysRevLett.89.198101
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Conduction block in one-dimensional heart fibers
Phys Rev Lett.
.
Abstract
We present a nonlinear dynamical systems analysis of the transition to conduction block in one-dimensional cardiac fibers. We study a simple model of wave propagation in heart tissue that depends only on the recovery of action potential duration and conduction velocity. If the recovery function has slope >or=1 and the velocity recovery function is nonconstant, rapid activation causes dynamical heterogeneity and finally conduction block away from the activation site. This dynamical mechanism may play a role in the initiation and breakup of spiral waves in excitable media.
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