Production of clinical-grade recombinant adeno-associated virus vectors
- PMID: 12459331
- DOI: 10.1016/s0958-1669(02)00369-5
Production of clinical-grade recombinant adeno-associated virus vectors
Abstract
Recombinant adeno-associated viral (rAAV) vectors are being evaluated in animal models and humans. Pre-clinical data demonstrating vector safety, efficiency and efficacy have been used to initiate human clinical trials. The clinical manufacture of rAAV vectors has supported phase I and phase II trials, showing that adeno-associated virus serotype 2 vectors are safe when administered to humans.
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